Evidence map›Paper›PMID 32247511›Full record

ReviewCellular immunology2020

Programmed T cell differentiation: Implications for transplantation.

Rebecca L Crepeau, Mandy L Ford

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Rebecca L CrepeauEmory Transplant Center, Department of Surgery, Emory University, 101 Woodruff Circle, Suite 5208, Atlanta, GA 30322, United States.
Mandy L FordEmory Transplant Center, Department of Surgery, Emory University, 101 Woodruff Circle, Suite 5208, Atlanta, GA 30322, United States. Electronic address: Mandy.Ford@emory.edu.
Emory University · US

Funding

CD11b: A Novel Alternate Receptor for CD154 during AlloimmunityR01AI152516 · NIAID · EMORY UNIVERSITY · PI FORD, MANDY L · 2020 to 2025
$4.6M
Determinants of T Cell Fate in Transplantation ToleranceR01AI073707 · NIAID · EMORY UNIVERSITY · PI FORD, MANDY L · 2008 to 2021
$4.0M
Advanced Research Training in Transplantation ScienceT32AI070081 · NIAID · EMORY UNIVERSITY · PI Mandy L Ford · 2006 to 2026
$3.1M
The Role of CD28 cosignaling molecules on anti-viral immune responses in Chronic Kidney DiseaseF32AI145150 · NIAID · EMORY UNIVERSITY · PI CREPEAU, REBECCA L · 2019 to 2019
$62k
NIAID NIH HHS F32 AI145150NIAID NIH HHS R01 AI073707NIAID NIH HHS R01 AI152516NIAID NIH HHS T32 AI070081
6 · The paper itself

Abstract

While T cells play a critical role in protective immunity against infection, they are also responsible for graft rejection in the setting of transplantation. T cell differentiation is regulated by both intrinsic transcriptional pathways as well as extrinsic factors such as antigen encounter and the cytokine milieu. Herein, we review recent discoveries in the transcriptional regulation of T cell differentiation and their impact on the field of transplantation. Recent studies uncovering context-dependent differentiation programs that differ in the setting of infection or transplantation will also be discussed. Understanding the key transcriptional pathways that underlie T cell responses in transplantation has important clinical implications, including development of novel therapeutic agents to mitigate graft rejection.

Indexed as

Organ TransplantationAnimalsCell DifferentiationGene Expression RegulationGraft RejectionHumansLymphocyte ActivationT-LymphocytesTranscription, GeneticTransplantation ToleranceEomesIRF4TbetT cell differentiationTissue-resident memoryTranscriptional regulationTransplantationTrm

Identifiers

PMID32247511
PMCPMC7198981
OpenAlexW3013881939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.