Evidence map›Paper›PMID 32247284›Full record

ArticleBiostatistics (Oxford, England)2022

A Bayesian nonparametric approach for evaluating the causal effect of treatment in randomized trials with semi-competing risks.

Yanxun Xu, Daniel Scharfstein, Peter Müller, Michael Daniels

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  3. Article
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  11. Causal inference for semi-competing risks data.Biostatistics (Oxford, England) · 2022
    Article
  12. Bayesian semi-parametric G-computation for causal inference in a cohort study with MNAR dropout and death.Journal of the Royal Statistical Society. Series C, Applied statistics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanxun XuDepartment of Applied Mathematics and Statistics, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA yanxun.xu@jhu.edu.
Daniel ScharfsteinDepartment of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA.
Peter MüllerDepartment of Mathematics, The University of Texas at Austin, 2515 Speedway, RLM 8.100, Austin, TX 78712, USA.
Michael DanielsDepartment of Statistics, University of Florida, Union Rd, Gainesville, FL 32603, USA.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
BAYESIAN APPROACHES FOR MISSINGNESS AND CAUSALITY IN CANCER AND BEHAVIOR STUDIESR01CA183854 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI DANIELS, MICHAEL J · 2014 to 2019
$1.7M
Non-Parametric Bayesian Methods for Causal InferenceR01GM112327 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ROY, JASON A · 2014 to 2017
$1.4M
NCI NIH HHS R01 CA183854NIAID NIH HHS P30 AI094189NIGMS NIH HHS R01 GM112327
6 · The paper itself

Abstract

We develop a Bayesian nonparametric (BNP) approach to evaluate the causal effect of treatment in a randomized trial where a nonterminal event may be censored by a terminal event, but not vice versa (i.e., semi-competing risks). Based on the idea of principal stratification, we define a novel estimand for the causal effect of treatment on the nonterminal event. We introduce identification assumptions, indexed by a sensitivity parameter, and show how to draw inference using our BNP approach. We conduct simulation studies and illustrate our methodology using data from a brain cancer trial. The R code implementing our model and algorithm is available for download at https://github.com/YanxunXu/BaySemiCompeting.

Indexed as

AlgorithmsBayes TheoremCausalityComputer SimulationHumansRandomized Controlled Trials as TopicBayesian nonparametricsBrain cancer trialCausal inferenceIdentification assumptionsPrincipal stratificationSensitivity analysis

Identifiers

PMID32247284
PMCPMC10448950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.