Evidence map›Paper›PMID 32247113›Full record

ArticleEuropean journal of medicinal chemistry2020

A potent photoreactive general anesthetic with novel binding site selectivity for GABA

Abdelrahman R Shalabi, Zhiyi Yu, Xiaojuan Zhou, Youssef Jounaidi, Hanwen Chen, Jiajia Dai, Daniel E Kent, Hua-Jun Feng, Stuart A Forman, Jonathan B Cohen and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Abdelrahman R ShalabiDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA.
Zhiyi YuDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA, 02115, USA. Electronic address: zhiyi_yu@sdu.edu.cn.
Xiaojuan ZhouDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA.
Youssef JounaidiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA.
Hanwen ChenDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA. Electronic address: hanwen.chen@qq.com.
Jiajia DaiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA. Electronic address: Jiajiadai123@hotmail.com.
Daniel E KentDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA; Department of Health Science, Northeastern University, 360 Huntington Ave, Boston, MA, 02115, USA.
Hua-Jun FengDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA.
Stuart A FormanDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA.
Jonathan B CohenDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA, 02115, USA.
Karol S BruzikDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA.
Keith W MillerDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA, 02114, USA. Electronic address: k_miller@helix.mgh.harvard.edu.
Harvard University · USUniversity of Illinois Chicago · USMassachusetts General Hospital · USNortheastern University · US

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 1999 to 2018
$33.6M
NIGMS NIH HHS P01 GM058448
6 · The paper itself

Abstract

The pentameric γ-aminobutyric acid type A receptors (GABA

Indexed as

Allosteric RegulationAnesthetics, GeneralAnimalsBinding SitesDose-Response Relationship, DrugHEK293 CellsHumansModels, MolecularMolecular StructurePhotochemical ProcessesPropofolReceptors, GABA-AStructure-Activity RelationshipXenopusAnesthetics, GeneralPropofolReceptors, GABA-ADiazirineGABA-A receptorGeneral anesthetics binding sitesPhotolabelingPositive allosteric modulatorTransmembrane domain

Identifiers

PMID32247113
PMCPMC7342775
OpenAlexW3013384716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.