Evidence map›Paper›PMID 32246983›Full record

ArticleExperimental eye research2020

Differentiation of soluble aqueous humor metabolites in primary open angle glaucoma and controls.

Ciara Myer, Jordan Perez, Leila Abdelrahman, Roberto Mendez, Ram B Khattri, Anna K Junk, Sanjoy K Bhattacharya

Open access · greenAbstract read
In one paragraph

Article in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Metabolomics in Glaucoma: A Systematic Review.Investigative ophthalmology & visual science · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ciara MyerBascom Palmer Eye Institute, University of Miami, Miami, FL, USA; Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA.
Jordan PerezBascom Palmer Eye Institute, University of Miami, Miami, FL, USA; Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA; Case Western Reserve University, Cleveland, OH, USA.
Leila AbdelrahmanBascom Palmer Eye Institute, University of Miami, Miami, FL, USA; Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA.
Roberto MendezBascom Palmer Eye Institute, University of Miami, Miami, FL, USA; Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA; Department of Surgery, University of Miami, Miami, FL, USA.
Ram B KhattriDepartment of Biochemistry and Molecular Biochemistry, University of Florida, Gainesville, FL, USA.
Anna K JunkBascom Palmer Eye Institute, University of Miami, Miami, FL, USA; Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA; Miami Veterans Affairs Health Care System, Miami, FL, USA.
Sanjoy K BhattacharyaBascom Palmer Eye Institute, University of Miami, Miami, FL, USA; Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA. Electronic address: sbhattacharya@med.miami.edu.
University of Miami · USMiami VA Healthcare System · USUniversity of Florida · US

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dmitry V Ivanov · 2004 to 2026
$12.2M
Southeast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2M
NEI NIH HHS P30 EY014801NIDDK NIH HHS U24 DK097209NIDDK NIH HHS U2C DK119886
6 · The paper itself

Abstract

We report an analysis of the aqueous humor (AH) metabolome of primary open angle glaucoma (POAG) in comparison to normal controls. The AH samples were obtained from human donors [control (n = 35), POAG (n = 23)]. The AH samples were subjected to one-dimensional

Indexed as

AgedAged, 80 and overAqueous HumorCase-Control StudiesCell DifferentiationEye ProteinsFemaleGlaucoma, Open-AngleHumansIntraocular PressureMaleMass SpectrometryMiddle AgedTrabecular MeshworkEye ProteinsAqueous humorGlaucomaIROAMetabolomicsNMRPOAG

Identifiers

PMID32246983
PMCPMC7229990
OpenAlexW3014464189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.