Evidence map›Paper›PMID 32246937›Full record

ArticleThe Annals of thoracic surgery2020

ST2 Predicts Risk of Unplanned Readmission Within 1 Year After Pediatric Congenital Heart Surgery.

Devin M Parker, Allen D Everett, Meagan E Stabler, Marshall L Jacobs, Jeffrey P Jacobs, Luca Vricella, Heather Thiessen-Philbrook, Chirag R Parikh, Cedric Manlhiot, Jeremiah R Brown

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Annals of thoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07029230 (Biomarker in Congenital Cardiac Surgery - sST2 Marker in Heart Failure in Congenital Heart Disease After Surgery Research and Translational Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07029230 recruitingnot on this mapstarted 2025, after this paper: background citation

Biomarker in Congenital Cardiac Surgery - sST2 Marker in Heart Failure in Congenital Heart Disease After Surgery Research and Translational Study

TypeobservationalSponsorMartin SchweigerRan2025 to 2029Enrolled225ConditionsCongenital Heart Surgery, Congenital Heart Disease in Children, Fontan Physiology
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Devin M ParkerThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, New Hampshire; Department of Epidemiology, Dartmouth Geisel School of Medicine, Hanover, New Hampshire. Electronic address: devin.m.parker.gr@dartmouth.edu.
Allen D EverettDivision of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Meagan E StablerDepartment of Epidemiology, Dartmouth Geisel School of Medicine, Hanover, New Hampshire.
Marshall L JacobsDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jeffrey P JacobsDivision of Cardiac Surgery, University of Florida, Gainesville, Florida.
Luca VricellaDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Heather Thiessen-PhilbrookDivision of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Chirag R ParikhDivision of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Cedric ManlhiotDivision of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jeremiah R BrownThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, New Hampshire; Department of Epidemiology, Dartmouth Geisel School of Medicine, Hanover, New Hampshire; Department of Biomedical Data Science, Geisel School of Medicine, Lebanon, New Hampshire.
Dartmouth College · USJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of Florida · US

Funding

Novel Biomarkers to Predict Readmission in Pediatric and Adult Heart SurgeryR01HL119664 · NHLBI · DARTMOUTH COLLEGE · PI BROWN, JEREMIAH R · 2014 to 2017
$3.2M
NHLBI NIH HHS R01 HL119664
6 · The paper itself

Abstract

backgroundApproximately 10% to 20% of children are readmitted after congenital heart surgery. Very little is known about biomarkers as predictors of risk of unplanned readmission after pediatric congenital heart surgery. Novel cardiac biomarker ST2 may be associated with risk of unplanned readmission. ST2 concentrations are believed to reflect cardiovascular stress and fibrosis. Our objective was to explore the relationship between pre- and postoperative ST2 biomarker levels and risk of readmission within 1 year after congenital heart surgery.

methodsWe prospectively enrolled pediatric patients aged < 18 years who underwent at least 1 congenital heart operation at Johns Hopkins Hospital from 2010 to 2014. Plasma samples were collected immediately before surgery and at the end of bypass. We used Kaplan-Meier survival analysis and multivariable Cox regression models to adjust for variables used in The Society of Thoracic Surgeons Congenital Heart Surgery Database mortality risk model.

resultsOf our cohort of 145 patients, we found 39 children with readmissions within 365 days. The median time to unplanned readmission was 54 days (interquartile range, 10-153). Kaplan-Meier analysis demonstrated a significant difference across terciles of pre- and postoperative ST2 biomarker levels. After adjustment, elevated serum levels of ST2 measured preoperatively and postoperatively were associated with increased risk of readmission (hazard ratio, 2.5-3.7; all P < .05).

conclusionsElevated levels of ST2 are significantly associated with increased risk of unplanned readmission within 1 year after pediatric congenital heart surgery. Novel serum biomarker ST2 can be used for risk stratification or estimating postsurgical prognosis.

Indexed as

Patient ReadmissionBiomarkersChildChild, PreschoolFemaleHeart Defects, CongenitalHumansInfantInterleukin-1 Receptor-Like 1 ProteinKaplan-Meier EstimateMalePostoperative ComplicationsPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesSurvival RateBiomarkersIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 Protein

Identifiers

PMID32246937
PMCPMC8961679
OpenAlexW3014618161

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.