ArticleEndocrine2020
The oral microbiome profile and biomarker in Chinese type 2 diabetes mellitus patients.
Article in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Advances in the study of oral microbiota in association with T2DM: a systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- Oral microbiota mediates the association of healthy dietary patterns with lower risk of advanced cardiovascular-kidney-metabolic syndrome.Nutrition & diabetes · 2026Article
- Metabolic syndrome-associated gut microbiota and plasma metabolite profiles in schizophrenia.Translational psychiatry · 2026Article
- Oral Microbiota and Type 2 Diabetes: Interactions, Potential Mechanisms, and Preventive Strategies.Microorganisms · 2026Review
- Comparative Analysis of Oral Microbiome in Indian Type 2 Diabetes Mellitus (T2DM) and Periodontitis Cohorts.Diseases (Basel, Switzerland) · 2026Article
- Reframing glucolipid metabolic disorders through the lens of the oral microbiome: from pathophysiological mechanisms to translational potential.Frontiers in nutrition · 2026Review
- Correlation analysis between tongue hyperspectral imaging and tongue coating microbiota and feasibility study for early screening of type 2 diabetes mellitus status.Frontiers in endocrinology · 2026Article
- Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases.Journal of oral microbiology · 2026Review
- Development and validation of embedded multilayer attention graph convolution neural network models for predicting gut microbe-disease associations.Frontiers in microbiology · 2026Article
- SupragingivalJournal of oral microbiology · 2026Article
- Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity.Frontiers in microbiology · 2026Review
- Modulatory Effects of Isolated Lactobacillus paracasei from Malaysian Water Kefir Grains on the Intestinal Barrier and Gut Microbiota in Diabetic Mice.Probiotics and antimicrobial proteins · 2025Article
- Oral-Gut Microbiota Crosstalk and Epigenetic Targets in Metabolic and Neuropsychiatric Diseases.Nutrients · 2025Review
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
- Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Exploring the genetic determinants of the oral microbiome's role in gastrointestinal cancer risk: Mendelian randomization and genetic correlation analysis in an East Asian population.Discover oncology · 2025Article
- Integrative analyses of 16S rDNA sequencing and serum metabolomics demonstrate significant roles for the oral microbiota and serum metabolites in post-kidney transplant diabetes mellitus.Microbiology spectrum · 2025Article
- Consensus approach to differential abundance analysis detects few differences in the oral microbiome of pregnant women due to pre-existing type 2 diabetes mellitus.Microbial genomics · 2025Article
- Effect of Oral Microbiota Composition on Metabolic Dysfunction-Associated Steatotic Liver Disease in the General Population.Journal of clinical medicine · 2025Article
- Distribution and Characteristics of Oral Pathogens According to Blood Glucose Levels in South Korean Health Examinees.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
purposeOral microbiota maintains a dynamic ecological balance with the host. However, a disruption in this balance can lead to oral diseases such as dental caries and periodontitis. Several studies suggest differences in microbial composition in the oral cavity between patients with T2DM and nondiabetic patients. However, there is inadequate oral microbiome-related data from Chinese patients with T2DM, and the difference in microbiome profile between Chinese patients with T2DM and other ethnicities needs to be investigated further.
methodOral swab samples were collected from 280 adult patients with T2DM and 162 healthy controls. Illumina sequencing was performed on oral samples targeting V1-V2 region of 16S rRNA gene and sequence analysis was carried in the QIIME.
resultsPatients with T2DM and healthy cohorts exhibited distinct oral microbial clusters based on principal coordinate analysis (PCoA). The Firmicutes/Bacteroidetes ratio increased in T2DM and T2DM patients presented significantly higher numbers of Neisseria, Streptococcus, Haemophilus, and Pseudomonas genera, and lower numbers of Acinetobacteria compared with healthy controls. When compared with the available published data of oral and gut microbiome associated with T2DM patients, we found the ratio of Firmicutes/Bacteroidetes and the abundance of Haemophilus could be a specific microbial biomarker in Chinese patients with T2DM.
conclusionsOur study revealed a significant difference in the oral microbiota between T2DM patients and healthy individuals. We identified 25 taxa, including 6 genera, with significant difference in abundance between T2DM and healthy controls.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.