ArticleScientific reports2020
Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- An intrascrotal bioadhesive nanoplatform for sustained hydrogen delivery ameliorates age-associated testicular dysfunction.Materials today. Bio · 2026Article
- Silicon-based agent mitigates fatty liver formation in a CDAHFD60-induced MASH mouse model by enhancing hepatic function.Biochemistry and biophysics reports · 2026Article
- Silicon-based agent alleviating intestinal ischemia/reperfusion injury in mice by inhibiting ferroptosis via activating AMPK-Sirt1 signaling pathway.Scientific reports · 2026Article
- Efficacy of silicon-based agent against aging-related frailty.Scientific reports · 2026Article
- Hydrogen: a review of the effects and underlying mechanisms in oral diseases.Frontiers in pharmacology · 2026Review
- Effect of Si-based agent on alcohol hangovers and liver damage caused by acute ethanol overdose.Biochemistry and biophysics reports · 2025Article
- Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice.Biomedicines · 2025Article
- Silicon Nanostructures for Hydrogen Generation and Storage.Nanomaterials (Basel, Switzerland) · 2025Review
- Efficacy of the silicon based agent for age related decline in vestibular function.Scientific reports · 2025Article
- Oxidative stress-induced NCC activation in the development of nocturnal polyuria in mice: Therapeutic potential of a sustained hydrogen-releasing silicon-based agent.Biochemistry and biophysics reports · 2025Article
- Role and mechanism of molecular hydrogen in the treatment of Parkinson's diseases.Frontiers in neuroscience · 2025Review
- Si-based agent alleviated small bowel ischemia-reperfusion injury through antioxidant effects.Scientific reports · 2024Article
- Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes.Molecules (Basel, Switzerland) · 2023Review
- Diverse Possibilities of Si-Based Agent, a Unique New Antioxidant.Antioxidants (Basel, Switzerland) · 2023Review
- Effect of the new silicon-based agent on the symptoms of interstitial pneumonitis.Scientific reports · 2023Article
- Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.Molecular neurobiology · 2023Review
- Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder.International journal of molecular sciences · 2023Review
- The development of a novel antioxidant-based antiemetic drug to improve quality of life during anticancer therapy.Biochemistry and biophysics reports · 2022Article
- Therapeutic strategy for facial paralysis based on the combined application of Si-based agent and methylcobalamin.Biochemistry and biophysics reports · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney rats and Parkinson's disease mice. Rats are fed with control or Si-based agent-containing diet for 8 weeks. Si-based agent is found to greatly suppress the development of renal failure and the parameters of oxidative stress. Treatment with Si-based agent in a mouse model of hemi-Parkinson's disease induced by 6-hydroxydopamine attenuated degeneration of dopaminergic neurons and prevented impairment of motor balance and coordination. These findings indicate that the Si-based agent shows renoprotective and neuroprotective effects presumably via suppression of oxidative stress by generation of hydrogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.