ArticleScientific reports2020
Milk lactoperoxidase decreases ID1 and ID3 expression in human oral squamous cell carcinoma cell lines.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment.Biomolecules · 2022Pooled it
- Influence of dairy products consumption on oral cancer risk: A meta-analysis.Journal of dental research, dental clinics, dental prospects · 2023Review
- RNAseq of TGF-β receptor type I kinase-dependent genes in oral fibroblast exposed to milk.BMC oral health · 2021Article
- Micellar Casein and Whey Powder Hold a TGF-β Activity and Regulate ID Genes In Vitro.Molecules (Basel, Switzerland) · 2021Article
- Effect of comprehensive nursing on the appearance and recovery effect of oral squamous cell carcinoma patients.American journal of translational research · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Milk consumption may modify the risk of squamous cell carcinoma. The role of milk to modulate the gene expression in oral squamous cell carcinoma cells has not been investigated so far. Here, HSC2 oral squamous carcinoma cells were exposed to an aqueous fraction of human milk and a whole-genome array was performed. Among the genes that were significantly reduced by human and cow milk were the DNA-binding protein inhibitor 1 (ID1), ID3 and Distal-Less Homeobox 2 (DLX2) in HSC2 cells. Also, in TR146 oral squamous carcinoma cells, there was a tendency towards a decreased gene expression. Upon size fractionation, lactoperoxidase but not lactoferrin and osteopontin was identified to reduce ID1 and ID3 in HSC2 cells. Dairy products and hypoallergenic infant formula failed to decrease the respective genes. These data suggest that milk can reduce the expression of transcription factors in oral squamous carcinoma cells.
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Registered trials
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