ArticleScientific reports2020
Genomic characterization and outcome of prosthetic joint infections caused by Staphylococcus aureus.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Insertion sequence elements associated with Staphylococcus epidermidis evolution in persistent orthopaedic device-related infections.BMC genomics · 2026Article
- Investigating the benefits of metagenomic next-generation sequencing for patients experiencing infections after total hip replacement surgery: a retrospective cohort study with a minimum of one year of follow-up.Frontiers in cellular and infection microbiology · 2026Article
- The requirement for total knee arthroplasty following surgical fixation of tibial plateau fractures.Bone & joint open · 2025Article
- The mutational landscape of Staphylococcus aureus during colonisation.Nature communications · 2025Article
- Immune Checkpoint Molecules as Biomarkers ofbioRxiv : the preprint server for biology · 2024Article
- [Study on effectiveness of antibiotics guided by metagenomic next-generation sequencing to control infection after total knee arthroplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Article
- Superantigen Encoding Genes in Staphylococcus aureus Isolated from Lesional Skin, Non-Lesional Skin, and Nares of Patients with Atopic Dermatitis.Acta dermato-venereologica · 2024Article
- SaLTy: a novelMicrobial genomics · 2024Article
- Next Generation Sequencing in orthopaedic infections - Where is the road headed?Journal of clinical orthopaedics and trauma · 2024Article
- Dogs can detect an odor profile associated withFrontiers in allergy · 2024Article
- Role ofOpen veterinary journal · 2023Article
- Promising applications of D-amino acids in periprosthetic joint infection.Bone research · 2023Review
- Advances in the Microbiological Diagnosis of Prosthetic Joint Infections.Diagnostics (Basel, Switzerland) · 2023Review
- A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses : a proof of principle study.Bone & joint research · 2023Article
- Functional analysis of intergenic regulatory regions of genes encoding surface adhesins inBiofilm · 2022Article
- Genomics of Staphylococcus aureus and Staphylococcus epidermidis from Periprosthetic Joint Infections and Correlation to Clinical Outcome.Microbiology spectrum · 2022Article
- Microbiological and Molecular Features Associated with Persistent and RelapsingAntibiotics (Basel, Switzerland) · 2022Article
- Molecular Approach for the Laboratory Diagnosis of Periprosthetic Joint Infections.Microorganisms · 2022Review
- Genomics ofAntibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is a commensal colonizing the skin and mucous membranes. It can also act as a pathogen, and is the most common microorganism isolated from prosthetic joint infections (PJIs). The aim of this study was to explore the genomic relatedness between commensal and PJI S. aureus strains as well as microbial traits and host-related risk factors for treatment failure. Whole-genome sequencing (WGS) was performed on S. aureus isolates obtained from PJIs (n = 100) and control isolates from nares (n = 101). Corresponding clinical data for the PJI patients were extracted from medical records. No PJI-specific clusters were found in the WGS phylogeny, and the distribution of the various clonal complexes and prevalence of virulence genes among isolates from PJIs and nares was almost equal. Isolates from patients with treatment success and failure were genetically very similar, while the presence of an antibiotic-resistant phenotype and the use of non-biofilm-active antimicrobial treatment were both associated with failure.In conclusion, commensal and PJI isolates of S. aureus in arthroplasty patients were genetically indistinguishable, suggesting that commensal S. aureus clones are capable of causing PJIs. Furthermore, no association between genetic traits and outcome could be demonstrated, stressing the importance of patient-related factors in the treatment of S. aureus PJIs.
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