ArticleScientific reports2020
Vascular Supply of the Human Spiral Ganglion: Novel Three-Dimensional Analysis Using Synchrotron Phase-Contrast Imaging and Histology.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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22 citing papers in PubMed, 34 citations in OpenAlex.
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- Development and Evaluation of a Novel Transcanal Catheter for Delivery of Hypothermia to the Inner Ear.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025Article
- The vascular anatomy of the internal auditory canal. A reappraisal for function preservation surgery.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Article
- Clinical Validation of Manual Measurement of Cochlea Length With Post-Operative Electrode Insertion Depth: A Pilot Study.Laryngoscope investigative otolaryngology · 2025Article
- Article
- A novel therapeutic pathway to the human cochlear nerve.Scientific reports · 2024Article
- Hard X-ray imaging and tomography at the Biomedical Imaging and Therapy beamlines of Canadian Light Source.Journal of synchrotron radiation · 2024Article
- Associations between diabetes mellitus and sensorineural hearing loss from humans and animal studies.Hearing research · 2024Review
- Clinical High-Resolution Imaging of the Inner Ear by Using Magnetic Resonance Imaging (MRI) and Cone Beam Computed Tomography (CBCT).Journal of personalized medicine · 2024Article
- Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas.Scientific reports · 2024Article
- Understanding the impact of modiolus porosity on stimulation of spiral ganglion neurons by cochlear implants.Scientific reports · 2024Article
- Parameterisation and Prediction of Intra-canal Cochlear Structures.Annals of biomedical engineering · 2024Article
- Clinical characteristics of patients diagnosed with bilateral sudden sensorineural hearing loss.Frontiers in neurology · 2024Article
- Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?International journal of molecular sciences · 2023Article
- Unlocking the human inner ear for therapeutic intervention.Scientific reports · 2022Article
- Identification of cranial nerve ganglia using sectioned images and three-dimensional models of a cadaver.The Korean journal of pain · 2022Article
- Multiscale photonic imaging of the native and implanted cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Embryology, Malformations, and Rare Diseases of the Cochlea.Laryngo- rhino- otologie · 2021Article
- Article
- Spike Generators and Cell Signaling in the Human Auditory Nerve: An Ultrastructural, Super-Resolution, and Gene Hybridization Study.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human spiral ganglion (HSG) cell bodies located in the bony cochlea depend on a rich vascular supply to maintain excitability. These neurons are targeted by cochlear implantation (CI) to treat deafness, and their viability is critical to ensure successful clinical outcomes. The blood supply of the HSG is difficult to study due to its helical structure and encasement in hard bone. The objective of this study was to present the first three-dimensional (3D) reconstruction and analysis of the HSG blood supply using synchrotron radiation phase-contrast imaging (SR-PCI) in combination with histological analyses of archival human cochlear sections. Twenty-six human temporal bones underwent SR-PCI. Data were processed using volume-rendering software, and a representative three-dimensional (3D) model was created to allow visualization of the vascular anatomy. Histologic analysis was used to verify the segmentations. Results revealed that the HSG is supplied by radial vascular twigs which are separate from the rest of the inner ear and encased in bone. Unlike with most organs, the arteries and veins in the human cochlea do not follow the same conduits. There is a dual venous outflow and a modiolar arterial supply. This organization may explain why the HSG may endure even in cases of advanced cochlear pathology.
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