Evidence map›Paper›PMID 32245901›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2020

Safety and Feasibility of PARP1/2 Imaging with

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts, Christian Brand, Milan Grkovski, Audrey Mauguen, Mark P Dunphy, Ronald A Ghossein and 7 more

Open access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Current status of radionuclide therapy targeting PARP in cancer: challenges and prospects.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Imaging poly(ADP-ribose) polymerase-1 (PARP1)Acta pharmaceutica Sinica. B · 2025
    Article
  8. Review
  9. Development and evaluation of aEJNMMI radiopharmacy and chemistry · 2025
    Article
  10. Review
  11. [Communications medicine · 2025
    Article
  12. Article
  13. Article
  14. Pharmacodynamic Activity of [JCO precision oncology · 2024
    Article
  15. [Journal of clinical medicine · 2024
    Review
  16. Imaging PARP Upregulation with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 2 countries.

Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. reinert@mskcc.org schoderh@mskcc.org.
Paula Demétrio De Souza FrançaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-4316-8834
Reiko NakajimaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Eva BurnaziRadiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York.
Sheryl RobertsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-2326-9120
Christian BrandDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-5157-662X
Milan GrkovskiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-7228-9497
Audrey MauguenDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-3236-6093
Mark P DunphyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ronald A GhosseinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Serge K LyashchenkoDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-7065-4534
Joseph A O'DonoghueDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-2761-0015
Ian GanlyDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Snehal G PatelDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Nancy Y LeeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. reinert@mskcc.org schoderh@mskcc.org.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204441NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

purposeWe performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with PATIENTS AND

methodsEleven patients with newly diagnosed or recurrent oral and oropharyngeal cancer were injected with

results

conclusionsImaging of head and neck cancer with

Indexed as

Fluorodeoxyglucose F18FemaleHead and Neck NeoplasmsHumansImmunohistochemistryMalePoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) PolymerasesPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsTissue DistributionFluorodeoxyglucose F18PARP1 protein, humanPARP2 protein, humanPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) PolymerasesRadiopharmaceuticals

Identifiers

PMID32245901
PMCPMC7421489
OpenAlexW3014754175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.