Evidence map›Paper›PMID 32245891›Full record

ArticleThe Journal of biological chemistry2020

The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation.

Hashem A Meriesh, Andrew M Lerner, Mahesh B Chandrasekharan, Brian D Strahl

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure.Biochimica et biophysica acta. Gene regulatory mechanisms · 2024
    Review
  4. An ascomycete H4 variant with an unknown function.Royal Society open science · 2024
    Article
  5. Protein arginine methylation in transcription and epigenetic regulation.Frontiers in epigenetics and epigenomics · 2023
    Review
  6. Article
  7. Review
  8. The SAGA continues: The rise of cis- and trans-histone crosstalk pathways.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hashem A MerieshDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599.
Andrew M LernerDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599.
Mahesh B ChandrasekharanDepartment of Radiation Oncology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112.ORCID 0000-0002-9956-8354
Brian D StrahlDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 brian_strahl@med.unc.edu.ORCID 0000-0002-4947-6259
University of North Carolina at Chapel Hill · USUniversity of Utah · US

Funding

Mechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5M
CANCER CELL BIOLOGY TRAINING PROGRAMT32CA071341 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHANNING J. DER, Yuliya Pylayeva-Gupta · 1996 to 2026
$5.0M
Structure, function and regulation of the H2B ubiquitin-conjugating complexR01GM127783 · NIGMS · UNIVERSITY OF UTAH · PI CHANDRASEKHARAN, MAHESH B · 2018 to 2022
$1.7M
NCI NIH HHS T32 CA071341NIGMS NIH HHS R01 GM127783NIGMS NIH HHS R35 GM126900
6 · The paper itself

Abstract

Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the

Indexed as

UbiquitinationAcetylationChromatinEndopeptidasesHistonesMutationOptogeneticsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTrans-ActivatorsBre1 protein, S cerevisiaeChromatinEndopeptidasesHistonesSaccharomyces cerevisiae ProteinsSAGA complex, S cerevisiaeTrans-ActivatorsUBP8 protein, S cerevisiaechromatinchromatin regulationgene transcriptionhistonehistone modificationyeast transcription

Identifiers

PMID32245891
PMCPMC7212633
OpenAlexW3014697913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.