Evidence map›Paper›PMID 32245808›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Gene drive and resilience through renewal with next generation

Georg Oberhofer, Tobin Ivy, Bruce A Hay

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Predicting the invasiveness of threshold-dependent gene drives.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes.Journal of visualized experiments : JoVE · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Georg OberhoferDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Tobin IvyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Bruce A HayDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; haybruce@caltech.edu.ORCID 0000-0002-5486-0482
California Institute of Technology · US

Funding

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIGMS NIH HHS T32 GM007616NIH HHS P40 OD018537
6 · The paper itself

Abstract

Gene drive-based strategies for modifying populations face the problem that genes encoding cargo and the drive mechanism are subject to separation, mutational inactivation, and loss of efficacy. Resilience, an ability to respond to these eventualities in ways that restore population modification with functional genes, is needed for long-term success. Here, we show that resilience can be achieved through cycles of population modification with "

Indexed as

Gene Drive TechnologyModels, GeneticAnimalsAnimals, Genetically ModifiedDrosophilaFemaleGenes, EssentialGenetics, PopulationHeterozygoteMaleModels, AnimalCas9gene drivepopulation replacementselfish genetic element

Identifiers

PMID32245808
PMCPMC7183144
OpenAlexW3014706282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.