ArticleCancer research2020
Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women.
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Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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33citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Breast Cancer-Protective Genetic Variant Common in Women of Indigenous American Genetic Ancestry Is a cis-eQTL for RMND1, ARMT1, and CCDC170 in HER2-Enriched Tumor Subtypes.Cancer research communications · 2026Article
- Molecular profiling of breast cancer in native American women reveals distinct genomic and transcriptomic features.NPJ precision oncology · 2026Article
- Cognitive changes associated with chemotherapy in breast cancer: an assessment of social cognition and executive functions in Peruvian patients.The oncologist · 2026Article
- Worse Clinical and Survival Outcomes in Breast Cancer Patients Living in Puerto Rico Compared to Hispanics, Non-Hispanic Blacks, and Non-Hispanic Whites from Florida.Journal of racial and ethnic health disparities · 2026Article
- Breast cancer clustering integrating complete gene expression profiles and genetic ancestry.PloS one · 2026Article
- Mapping pesticide mixtures to cancer risk at the country scale with spatial exposomics.Nature health · 2026Article
- Association between ancestry and tumor somatic mutations in a large national cohort of women with breast cancer.NPJ breast cancer · 2025Article
- Genetic Ancestry, Intrinsic Tumor Subtypes, and Breast Cancer Survival in Latin American Women.Cancer research communications · 2025Article
- Creation and Characterization of a Breast Cancer Tissue Microarray Including Black and White Patients from Florida and Hispanic Patients from Puerto Rico and Florida.Cancer research communications · 2025Article
- Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants inFrontiers in oncology · 2025Review
- Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry.Nature medicine · 2024Article
- Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium.Cancer research communications · 2024Article
- Diagnostic potential of exosomal extracellular vesicles in oncology.BMC cancer · 2024Review
- Genetic ancestry is related to potential sources of breast cancer health disparities among Colombian women.PloS one · 2024Article
- Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers.Breast cancer research : BCR · 2023Article
- Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics.Cancer research · 2023Article
- Development and testing of a polygenic risk score for breast cancer aggressiveness.NPJ precision oncology · 2023Article
- Breast cancer subtype and clinical characteristics in women from Peru.Frontiers in oncology · 2023Article
- HomodimerMedical oncology (Northwood, London, England) · 2022Article
Corrections and comments
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Authors and funding
39 authors at 13 institutions in 4 countries.
Katie M MarkerDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Valentina A ZavalaDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.ORCID 0000-0003-2040-1760
Tatiana VidaurreInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.ORCID 0000-0003-1995-4560
Paul C LottUC Davis Genome Center, University of California, Davis, Davis, California.ORCID 0000-0002-1611-442X
Jeannie Navarro VásquezInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Sandro Casavilca-ZambranoInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.ORCID 0000-0001-8406-739X
Mónica CalderónInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Julio E AbugattasInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.ORCID 0000-0002-9806-0989
Henry L GómezInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.ORCID 0000-0003-2660-1843
Hugo A FuentesInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Ruddy Liendo PicoagaInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Jose M CotrinaInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Silvia P NeciosupInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.ORCID 0000-0002-2657-9853
Carlos A CastañedaInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Zaida MoranteInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Fernando ValenciaInstituto Nacional de Enfermedades Neoplásicas, Lima, Peru.ORCID 0000-0003-2475-0570
Javier TorresUnidad de Investigación en Enfermedades Infecciosas, Instituto Mexicano del Seguro Social; México City, México.ORCID 0000-0003-3945-4221
Magdalena EcheverryGrupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultades de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia.
Mabel E BohórquezGrupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultades de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia.
Guadalupe Polanco-EcheverryUC Davis Genome Center, University of California, Davis, Davis, California.
Ana P Estrada-FlorezUC Davis Genome Center, University of California, Davis, Davis, California.ORCID 0000-0001-5480-693X
Silvia J Serrano-GómezGrupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá, Colombia.
Jenny A Carmona-ValenciaDinamica IPS, Medellín, Colombia.
Isabel Alvarado-CabreroHospital de Oncología de Centro Médico Nacional Siglo XXI, México City, México.ORCID 0000-0003-4000-9280
María Carolina Sanabria-SalasSubdirección de Investigaciones - Instituto Nacional de Cancerología, Bogotá, Colombia.
Alejandro VelezDinamica IPS, Medellín, Colombia.
Jorge DonadoHospital Pablo Tobon Uribe, Medellín, Colombia.
Sikai SongDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Daniel CherryDepartment of Medicine, University of California San Diego, San Diego, California.
Lizeth I TamayoDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois.ORCID 0000-0002-2417-3331
Scott HuntsmanDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Donglei HuDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.ORCID 0000-0002-0351-001X
Roberto Ruiz-CorderoDepartment of Pathology, University of California, San Francisco, California.ORCID 0000-0002-9747-6069
Ronald BalassanianDepartment of Pathology, University of California, San Francisco, California.ORCID 0000-0001-5756-9052
Elad ZivDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Jovanny ZabaletaStanley S. Scott Cancer Center, LSUHSC, New Orleans, Louisiana.
Luis Carvajal-Carmona
Laura FejermanDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California. laura.fejerman@ucsf.edu.
COLUMBUS Consortium
Instituto Nacional de Enfermedades Neoplásicas · PESan Francisco General Hospital · USUniversity of California, Davis · USUniversity of Tolima · COInstituto Nacional de Cancerología · COMunicipality of Medellín · COUniversity of California, San Francisco · USCentro Medico Nacional Siglo XXI · MXChicago Department of Public Health · USHospital Pablo Tobon Uribe · COLouisiana Cancer Research Center · USMexican Social Security Institute · MXUniversity of San Diego · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M Tissue &PathologyP50CA093372 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2001 to 2009
$15.4MGermline and Tumor Genomic Analyses of Breast Cancer in LatinasR01CA184585 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NEUHAUSEN, SUSAN L., ZIV, ELAD · 2014 to 2018
$4.2M(PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactionsR01CA227237 · NCI · DANA-FARBER CANCER INST · PI GUSEV, ALEXANDER, ZAITLEN, NOAH A · 2018 to 2022
$3.5MBiological implications of breast cancer protective variants in Latin Americanwomen with high Indigenous American ancestryR01CA204797 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEJERMAN, LAURA · 2016 to 2020
$1.9MGenetics of mammographic density and breast cancer risk in LatinasK24CA169004 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2012 to 2021
$1.8MPilot ProjectP20CA202922 · NCI · LSU HEALTH SCIENCES CENTER · PI MIELE, LUCIO · 2017 to 2020
$987kNCI NIH HHS K24 CA169004NCI NIH HHS P20 CA202922NCI NIH HHS P30 CA033572NCI NIH HHS P50 CA093372NCI NIH HHS R01 CA184585NCI NIH HHS R01 CA204797NCI NIH HHS R01 CA227237
Abstract
Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk of mortality than non-Hispanic White women. Studies in U.S. Latinas and Latin American women have reported a high incidence of HER2 positive (+) tumors; however, the factors contributing to this observation are unknown. Genome-wide genotype data for 1,312 patients from the Peruvian Genetics and Genomics of Breast Cancer Study (PEGEN-BC) were used to estimate genetic ancestry. We tested the association between HER2 status and genetic ancestry using logistic and multinomial logistic regression models. Findings were replicated in 616 samples from Mexico and Colombia. Average Indigenous American (IA) ancestry differed by subtype. In multivariate models, the odds of having an HER2
Indexed as
AdultAgedAsian PeopleBlack or African AmericanBlack PeopleBreast NeoplasmsColombiaErb-b2 Receptor Tyrosine KinasesFemaleHispanic or LatinoHumansIndians, North AmericanIndians, South AmericanLatin AmericaLinear ModelsLogistic ModelsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenReceptors, Progesterone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.