Evidence map›Paper›PMID 32245476›Full record

ArticleBiomedical engineering online2020

Remineralization of dentin slices using casein phosphopeptide-amorphous calcium phosphate combined with sodium tripolyphosphate.

Zhou Zhou, Xingyun Ge, Minxia Bian, Tao Xu, Na Li, Jiamin Lu, Jinhua Yu

Open access · goldAbstract read
In one paragraph

Article in Biomedical engineering online, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

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  6. [Influence of two methods of smear layer removal on the surface properties of dentin].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhou ZhouInstitute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Xingyun GeInstitute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Minxia BianInstitute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Tao XuKey Laboratory of Oral Diseases of Jiangsu Province and Stomatological Institute of Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Na LiInstitute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Jiamin LuInstitute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Jinhua YuInstitute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China. yuziyi_yjh@hotmail.com.ORCID http://orcid.org/0000-0003-4874-9910
Nanjing Medical University · CN

Funding

Innovative Research Group Project of the National Natural Science Foundation of China (CN) 81873707National Natural Science Foundation of China 81600822Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX19_1147Priority Academic Program Development of Jiangsu Higher Education Institutions 2018-87Priority Academic Program Development of Jiangsu Higher Education Institutions PAPDScience and Technology Development Project of Jiangsu Province BE2017731SuYan Research & Development Funds for Intelligent Health Science & Technology Innovation NMU-SY201804
6 · The paper itself

Abstract

backgroundThe remineralization approach mechanically occludes the exposed dentinal tubules mechanically, reduces the permeability of dentinal tubules and eliminates the symptoms of dentin hypersensitivity. The aim of the present study was to investigate the remineralization of demineralized dentin slices using CPP-ACP combined with TPP, and the research hypothesis was that CPP-ACP combined with TPP could result in extrafibrillar and intrafibrillar remineralization of dentin.

methodsDemineralized dentin slices were prepared and randomly divided into the following groups: A (the CPP-ACP group), B (the CPP-ACP + TPP combination group), C (the artificial saliva group), D (the negative control group), and E (the positive control group). Dentin slice samples from groups A, B and C were remineralized and the remineralization effect was evaluated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray diffraction (XRD).

resultsTreatment with CPP-ACP combined with TPP occluded the dentinal tubules and resulted in remineralization of collagen fibrils. The hydroxyapatite crystals formed via remineralization were found to closely resemble the natural dentin components.

conclusionCPP-ACP combined with TPP has a good remineralization effect on demineralized dentin slices.

Indexed as

CaseinsDentinDrug InteractionsHumansMineralsPolyphosphatescasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseinsMineralsPolyphosphatestriphosphoric acidCPP–ACPDemineralized dentin slicesRemineralizationTPP

Identifiers

PMID32245476
PMCPMC7119276
OpenAlexW3014443201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.