Evidence map›Paper›PMID 32245394›Full record

ArticleActa neuropathologica communications2020

KLF4

Niklas von Spreckelsen, Natalie Waldt, Rebecca Poetschke, Christoph Kesseler, Hildegard Dohmen, Hui-Ke Jiao, Attila Nemeth, Stefan Schob, Cordula Scherlach, Ibrahim Erol Sandalcioglu and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  12. Molecular neuropathology of brain-invasive meningiomas.Brain pathology (Zurich, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 2 countries.

Niklas von SpreckelsenDepartment of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Natalie WaldtDepartment of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Rebecca PoetschkeInstitute of Molecular Medicine, Martin Luther University, Halle/Saale, Germany.
Christoph KesselerDepartment of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Hildegard DohmenDepartment of Neuropathology, University Giessen, Giessen, Germany.
Hui-Ke JiaoDepartment of Neuropathology, University Giessen, Giessen, Germany.
Attila NemethDepartment of Neuropathology, University Giessen, Giessen, Germany.
Stefan SchobDepartment of Neuroradiology, University Hospital Leipzig, Leipzig, Germany.
Cordula ScherlachDepartment of Neuroradiology, University Hospital Leipzig, Leipzig, Germany.
Ibrahim Erol SandalciogluDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Martina DeckertDepartment of Neuropathology, University Hospital Cologne, Cologne, Germany.
Frank AngensteinLaboratory for Non-invasive Imaging, DZNE, Magdeburg, Germany.
Boris KrischekDepartment of Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Pantelis StavrinouDepartment of Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Marco TimmerDepartment of Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Marc RemkePediatric Neuro-Oncology, Duesseldorf, Germany.
Elmar KirchesDepartment of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Roland GoldbrunnerDepartment of Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
E Antonio ChioccaDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Stefan HuettelmaierInstitute of Molecular Medicine, Martin Luther University, Halle/Saale, Germany.
Till AckerDepartment of Neuropathology, University Giessen, Giessen, Germany.
Christian MawrinDepartment of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany. christian.mawrin@med.ovgu.de.
Otto-von-Guericke University Magdeburg · DEGiessen School of Theology · DEUniversity Hospital Cologne · DEMartin Luther University Halle-Wittenberg · DEUniversity Hospital Leipzig · DEUniversity of Cologne · DEHarvard University · US

Funding

Deutsche Forschungsgemeinschaft MA2530/6-1Deutsche Krebshilfe 70112956
6 · The paper itself

Abstract

Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however, have largely remained elusive. Here we report that the Krueppel like factor 4 (KLF4)-K409Q mutation in skull base meningiomas triggers a distinct tumor phenotype. Transcriptomic analysis of 17 meningioma samples revealed that KLF4

Indexed as

AnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitKruppel-Like Factor 4Kruppel-Like Transcription FactorsMechanistic Target of Rapamycin Complex 1Meningeal NeoplasmsMeningiomaMiceMice, NudeMutationNeoplasm TransplantationHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsMechanistic Target of Rapamycin Complex 1Prolyl HydroxylasesProtein Kinase InhibitorsSirolimustemsirolimusEdemaHIFHypoxiaK409QKLF4MeningiomaMutation

Identifiers

PMID32245394
PMCPMC7118946
OpenAlexW3015150402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.