ArticleBMC infectious diseases2020
Molecular characterization of human Echinococcus isolates and the first report of E. canadensis (G6/G7) and E. multilocularis from the Punjab Province of Pakistan using sequence analysis.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Alveolar Echinococcosis in the Early 2020s: A Systematic Review.Pathogens (Basel, Switzerland) · 2026Pooled it
- Echinococcus granulosus sensu lato Genotypes in Different Hosts Worldwide: A Systematic Review.Acta parasitologica · 2022Pooled it
- Equine alveolar echinococcosis: a focus on epidemiology, clinical and pathological features, and diagnostics.Journal of equine science · 2026Review
- Bioinformatics-Driven Design of Fusion Recombinant Protein (EgFABP1-EgTeg) for Enhanced Immunodiagnosis of Hydatid Cysts.Immunity, inflammation and disease · 2026Article
- Molecular epidemiology and phylogenetic analysis of Echinococcus spp. in the Qinghai-Tibetan Plateau: unraveling genetic evolution in a high-risk region for echinococcosis.Veterinary research communications · 2025Article
- Design and evaluation of a novel direct hemagglutination test based on a recombinant protein for diagnosis of cystic echinococcosis.Parasites & vectors · 2025Article
- Prevalence and molecular characterization of cystic echinococcosis in livestock in the Hazara Division, Pakistan.Frontiers in veterinary science · 2025Article
- Molecular phylogenetic analysis ofFood and waterborne parasitology · 2024Article
- Survey and Molecular Characterization of Echinococcus granulosus sensu stricto from Livestock and Humans in the Altai Region of Xinjiang, ChinaPathogens (Basel, Switzerland) · 2023Article
- Molecular Epidemiology of Cystic Echinococcosis in Rural Baluchistan, Pakistan: A Cross-Sectional Study.Pathogens (Basel, Switzerland) · 2022Article
- Insights into Human Cystic Echinococcosis in the Kurdistan Region, Iraq: Characteristics and Molecular Identification of Cysts.Pathogens (Basel, Switzerland) · 2022Article
- A Retrospective Cohort Study on Human Cystic Echinococcosis in Khyber Pakhtunkhwa Province (Pakistan) Based on 16 Years of Hospital Discharge Records.Pathogens (Basel, Switzerland) · 2022Article
- Occurrence and genetic characterization of Echinococcus granulosus sensu lato from domestic animals in Central Iran.BMC veterinary research · 2022Article
- Genetic diversity and haplotypes of paediatric hydatid cyst isolates and first occurrence ofParasitology · 2021Article
- Echinococcoses in Iran, Turkey, and Pakistan: Old Diseases in the New Millennium.Clinical microbiology reviews · 2021Article
- Demographics of Cystic Echinococcosis Patients Treated Surgically in Lahore, Pakistan: A Single Centre Study from 2007 - 2018.Helminthologia · 2021Article
- Establishing and evaluation of a polymerase chain reaction for the detection of Echinococcus multilocularis in human tissue.PLoS neglected tropical diseases · 2021Article
- Investigation of Echinococcus multilocularis in foxes and dogs in Pakistan by detection of copro-DNA.Parasitology research · 2021Article
- Prevalence and Molecular Characterization of Cystic Echinococcosis in Livestock Population of the Malakand Division, Khyber Pakhtunkhwa, Pakistan.Frontiers in veterinary science · 2021Article
- Investigation of MitochondrialIranian journal of parasitologyArticle
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8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundEchinococcosis is a zoonotic parasitic disease causing serious health problems in both humans and animals in different endemic regions across the world. There are two different forms of human echinococcosis: Cystic Echinococcosis (CE) and Alveolar Echinococcosis (AE). CE is caused by the larval stage of Echinococcus granulosus sensu lato and AE by the larval stage of Echinococcus multilocularis. Geographically, CE is universally distributed, while AE is prevalent in the northern hemisphere. Although the disease is endemic in neighboring countries (China, Iran and India) of Pakistan, there are limited reports from that country. Besides, there are no comprehensive data on the genotyping of Echinococcus species in humans based on sequence analysis. This study aimed to detect the presence of human CE and to identify Echinococcus spp. in human isolates through genetic characterization of hydatid cysts in the Punjab Province of Pakistan.
methodsGenetic analysis was performed on 38 human hydatid cyst samples collected from patients with echinococcosis using mitochondrial cytochrome c oxidase subunit 1 (cox1), cytochrome b (cytb) and NADH subunit 1 (nad1). Patient data including age, epidemiological history, sex, and location were obtained from hospital records.
resultsAccording to the sequence analysis we detected E. granulosus sensu stricto (n = 35), E. canadensis (G6/G7) (n = 2), and E. multilocularis (n = 1). Thus, the majority of the patients (92.1%, 35/38) were infected with E. granulosus s.s. This is the first molecular confirmation of E. canadensis (G6/G7) and E. multilocularis in human subjects from Pakistan.
conclusionsThese findings suggested that E. granulosus s.s. is the dominant species in humans in Pakistan. In addition, E. canadensis (G6/G7) and E. multilocularis are circulating in the country. Further studies are required to explore the genetic diversity in both humans and livestock.
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