ArticleBMC infectious diseases2020
Hepatitis E virus outbreak associated with rainfall in the Central African Republic in 2008-2009.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Systematic review of global hepatitis E outbreaks to inform response and coordination initiatives.BMC public health · 2023Pooled it
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- Effects of host sex, age and behaviour on co-infection patterns in a wild ungulate.Parasitology · 2025Article
- Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis.Tropical medicine and health · 2025Article
- Meteorological determinants of hepatitis E dynamics in Jiangsu Province, China: a pre-COVID-19 era study focusing on multi-route transmission (2005-2018).Frontiers in public health · 2025Article
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- The 2023 South Sudanese outbreak of Hepatitis E emphasizes ongoing circulation of genotype 1 in North, Central, and East Africa.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024Article
- Hepatitis E outbreak in the health district of Bocaranga-Koui, Central African Republic, 2018-2019.BMC infectious diseases · 2024Article
- Article
- Investigating animal reservoirs for hepatitis E virus in Bangui, Central African Republic.PloS one · 2024Article
- Deep learning models for hepatitis E incidence prediction leveraging meteorological factors.PloS one · 2023Article
- Climate change and emergency care in Africa: A scoping review.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2022Article
- Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus.Viruses · 2021Review
- Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health.Pathogens (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfection by hepatitis E virus (HEV) can cause a high burden of morbidity and mortality in countries with poor access to clean water and sanitation. Our study aimed to investigate the situation of HEV infections in the Central African Republic (CAR).
methodsA retrospective analysis of the blood samples and notification forms collected through the national yellow fever (YF) surveillance program, but for which a diagnosis of YF was discarded, was carried out using an anti-HEV IgM ELISA and a HEV-specific RT-PCR.
resultsOf 2883 YF-negative samples collected between January 2008 and December 2012, 745 (~ 26%) tested positive by at least either of the 2 tests used to confirm HEV cases. The results revealed that the CAR was hit by a large HEV outbreak in 2008 and 2009. The results also showed a clear seasonal pattern with correlation between HEV incidence and rainfall in Bangui. A phylogenetic analysis showed that the circulating strains belonged to genotypes 1e and 2b.
conclusionsOverall, this study provides further evidences that HEV can be a significant cause of acute febrile jaundice, particularly among adults during rainy season or flood, in a country from Sub-Saharan Africa.
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