In one paragraphArticle in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors at 4 institutions in 2 countries.
Abdelsattar M OmarDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-9825-3465 Mahmoud A ElfakyDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-3931-9353 Stefan T AroldComputational Bioscience Research Center, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia.
Sameh H SororCenter for Scientific Excellence Helwan Structural Biology Research (HSBR), Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo 11795, Egypt.ORCID 0000-0001-6474-8884 Maan T KhayatDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah 21589, Saudi Arabia.
Hani Z AsfourDepartment of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Faida H BamaneDepartment of Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Moustafa E El-ArabyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-7932-2226 King Abdulaziz University · SAAl-Azhar University · EGHelwan University · EGKing Abdullah University of Science and Technology · SA
Funding
King Abdulaziz City for Science and Technology 12-BIO3193-03King Abdullah University of Science and Technology N/A
6 · The paper itselfAbstract
The nonstructural (NS) protein NS3/4A protease is a critical factor for hepatitis C virus (HCV) maturation that requires activation by NS4A. Synthetic peptide mutants of NS4A were found to inhibit NS3 function. The bridging from peptide inhibitors to heterocyclic peptidomimetics of NS4A has not been considered in the literature and, therefore, we decided to explore this strategy for developing a new class of NS3 inhibitors. In this report, a structure-based design approach was used to convert the bound form of NS4A into 1
Indexed as
DEAD-box RNA HelicasesHepatitis CIntracellular Signaling Peptides and ProteinsNucleoside-TriphosphatasePeptidomimeticsSerine EndopeptidasesSerine Proteinase InhibitorsViral Nonstructural ProteinsViral ProteasesDEAD-box RNA HelicasesIntracellular Signaling Peptides and ProteinsNS3 protein, hepatitis C virusNS4A cofactor peptide, Hepatitis C virusNucleoside-TriphosphatasePeptidomimeticsSerine EndopeptidasesSerine Proteinase InhibitorsViral Nonstructural ProteinsViral Proteasesallosteric inhibitorsbinding assayDSLSFlaviviridaehepatitis C virusimidazolemolecular dynamicsNS3 inhibitorsNS4Apeptidomimetics
Identifiers
PMID32245218
PMCPMC7175367
OpenAlexW3002293819
What OpenQuestion holds
Textmetadata
LicenceCC BY
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