Evidence map›Paper›PMID 32245200›Full record

ArticleToxins2020

αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish.

Matthew J Rybin, Henrik O'Brien, Iris Bea L Ramiro, Layla Azam, J Michael McIntosh, Baldomero M Olivera, Helena Safavi-Hemami, Doju Yoshikami

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Malacologia · 2025
    Article
  3. Prey Shifts Drive Venom Evolution in Cone Snails.Molecular biology and evolution · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Matthew J RybinDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-8578-0891
Henrik O'BrienDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.
Iris Bea L RamiroDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3971-3107
Layla AzamDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.
J Michael McIntoshDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.
Baldomero M OliveraDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.
Helena Safavi-HemamiDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-1984-2721
Doju YoshikamiDepartment of Biology, University of Utah, Salt Lake City, UT 84112, USA.
University of Utah · USUniversity of Copenhagen · DKUniversity of Miami · US

Funding

Venoms, Biological Resources, Molecular BiologyP01GM048677 · NIGMS · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 1993 to 2018
$32.2M
NIGMS NIH HHS P01 GM048677NIH HHS GM048677Velux Foundation 19063
6 · The paper itself

Abstract

We report the discovery and functional characterization of αM-Conotoxin MIIIJ, a peptide from the venom of the fish-hunting cone snail

Indexed as

Action PotentialsAmino Acid SequenceAnimalsConotoxinsDose-Response Relationship, DrugExcitatory Postsynaptic PotentialsGoldfishMiceMuscle, SkeletalNeuromuscular JunctionNicotinic AntagonistsParesisPredatory BehaviorProtein BindingReceptors, NicotinicSequence AlignmentConotoxinsNicotinic AntagonistsReceptors, Nicotinicconotoxinneuromuscular junctionnicotinic acetylcholine receptorvenom

Identifiers

PMID32245200
PMCPMC7150935
OpenAlexW3015038879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.