ArticleInternational journal of molecular sciences2020
The Role of Dorsal Raphe Serotonin Neurons in the Balance between Reward and Aversion.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats.Psychopharmacology · 2026Article
- Review
- Conditioned versus innate effort-based tasks reveal divergence in antidepressant effect on motivational state in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Absence of TAAR1 function increases methamphetamine-induced excitability of dorsal raphe serotonin neurons and drives binge-level methamphetamine intake.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Functional Diversity of Serotonin Neurons in the Dorsal and Median Raphe Nuclei in Emotional Responses.Neuropsychopharmacology reports · 2025Review
- Optogenetic Stimulation of Novel Tph2-Cre Rats Advances Insight into Serotonin's Role in Locomotion, Reinforcement, and Compulsivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Role of serotonin neurons in the dorsal raphe nucleus in heroin self-administration and punishment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Complementary roles of serotonin and dopamine in model-based learning.Current opinion in behavioral sciences · 2025Article
- Dorsal Raphe Serotonergic Neurons-Ventral Tegmental Area Neural Pathway Promotes Wake From Sleep.CNS neuroscience & therapeutics · 2024Article
- Optimization of AAV vectors for transactivator-regulated enhanced gene expression within targeted neuronal populations.iScience · 2024Article
- Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation.Nature communications · 2024Article
- Requisite role of dorsal raphé in contextual cocaine-memory reconsolidation.Neuropharmacology · 2024Article
- The differential effect of optogenetic serotonergic manipulation on sustained motor actions and waiting for future rewards in mice.Frontiers in neuroscience · 2024Article
- μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges.Frontiers in pharmacology · 2023Review
- Inhibition of SK Channels in VTA Affects Dopaminergic Neurons to Improve the Depression-Like Behaviors of Post-Stroke Depression Rats.Neuropsychiatric disease and treatment · 2023Article
- Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.Nature communications · 2022Article
- Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest.iScience · 2022Article
- Effect of Co-Treatment of Olanzapine with SEP-363856 in Mice Models of Schizophrenia.Molecules (Basel, Switzerland) · 2022Article
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- Serotonergic regulation of the dopaminergic system: Implications for reward-related functions.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundReward processing is fundamental for animals to survive and reproduce. Many studies have shown the importance of dorsal raphe nucleus (DRN) serotonin (5-HT) neurons in this process, but the strongly correlative link between the activity of DRN 5-HT neurons and rewarding/aversive potency is under debate. Our primary objective was to reveal this link using two different strategies to transduce DRN 5-HT neurons.
methodsFor transduction of 5-HT neurons in wildtype mice, adeno-associated virus (AAV) bearing the mouse tryptophan hydroxylase 2 (TPH2) gene promoter was used. For transduction in Tph2-tTA transgenic mice, AAVs bearing the tTA-dependent TetO enhancer were used. To manipulate the activity of 5-HT neurons, optogenetic actuators (CheRiff, eArchT) were expressed by AAVs. For measurement of rewarding/aversive potency, we performed a nose-poke self-stimulation test and conditioned place preference (CPP) test.
resultsWe found that stimulation of DRN 5-HT neurons and their projections to the ventral tegmental area (VTA) increased the number of nose-pokes in self-stimulation test and CPP scores in both targeting methods. Concomitantly, CPP scores were decreased by inhibition of DRN 5-HT neurons and their projections to VTA.
conclusionOur findings indicate that the activity of DRN 5-HT neurons projecting to the VTA is a key modulator of balance between reward and aversion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.