Evidence map›Paper›PMID 32245175›Full record

ArticleBiomolecules2020

PIRT the TRP Channel Regulating Protein Binds Calmodulin and Cholesterol-Like Ligands.

Nicholas J Sisco, Dustin D Luu, Minjoo Kim, Wade D Van Horn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.International journal of molecular sciences · 2023
    Review
  2. Review
  3. Calmodulin as CaInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicholas J SiscoThe School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0003-2091-868X
Dustin D LuuThe School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
Minjoo KimThe School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
Wade D Van HornThe School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-2493-5578
Arizona State University · US

Funding

PIRT Family Modulation of TRPM8R01GM112077 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI VAN HORN, WADE D. · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM112077
6 · The paper itself

Abstract

Transient receptor potential (TRP) ion channels are polymodal receptors that have been implicated in a variety of pathophysiologies, including pain, obesity, and cancer. The capsaicin and heat sensor TRPV1, and the menthol and cold sensor TRPM8, have been shown to be modulated by the membrane protein PIRT (Phosphoinositide-interacting regulator of TRP). The emerging mechanism of PIRT-dependent TRPM8 regulation involves a competitive interaction between PIRT and TRPM8 for the activating phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

CalmodulinCholesterolHumansLigandsMembrane ProteinsProtein BindingTRPM Cation ChannelsTRPV Cation ChannelsCalmodulinCholesterolLigandsMembrane ProteinsPIRT protein, humanTRPM8 protein, humanTRPM Cation ChannelsTRPV1 protein, humanTRPV Cation Channelscalmodulinmicroscale thermophoresisnuclear magnetic resonancePIP2PIRTTRP channelsβ-estradiol

Identifiers

PMID32245175
PMCPMC7175203
OpenAlexW3012388139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.