Evidence map›Paper›PMID 32245158›Full record

ArticleCells2020

Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca

Olga Cozzolino, Federico Sicca, Emanuele Paoli, Francesco Trovato, Filippo M Santorelli, Gian Michele Ratto, Maria Marchese

Abstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  6. Dapagliflozin ameliorates Lafora disease phenotype in a zebrafish model.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
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  9. Review
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  16. Trehalose Treatment in Zebrafish Model of Lafora Disease.International journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olga CozzolinoNational Enterprise for Nanoscience and Nanotechnology (NEST), Istituto Nanoscienze Consiglio Nazionale delle Ricerche (CNR) and Scuola Normale Superiore Pisa, 56127 Pisa, Italy.ORCID 0000-0002-8218-8961
Federico SiccaMolecular Medicine, IRCCS Fondazione Stella Maris, Via dei Giacinti 2, 56028 Pisa, Italy.ORCID 0000-0002-4917-5253
Emanuele PaoliNational Enterprise for Nanoscience and Nanotechnology (NEST), Istituto Nanoscienze Consiglio Nazionale delle Ricerche (CNR) and Scuola Normale Superiore Pisa, 56127 Pisa, Italy.
Francesco TrovatoNational Enterprise for Nanoscience and Nanotechnology (NEST), Istituto Nanoscienze Consiglio Nazionale delle Ricerche (CNR) and Scuola Normale Superiore Pisa, 56127 Pisa, Italy.
Filippo M SantorelliMolecular Medicine, IRCCS Fondazione Stella Maris, Via dei Giacinti 2, 56028 Pisa, Italy.ORCID 0000-0002-1359-9062
Gian Michele RattoNational Enterprise for Nanoscience and Nanotechnology (NEST), Istituto Nanoscienze Consiglio Nazionale delle Ricerche (CNR) and Scuola Normale Superiore Pisa, 56127 Pisa, Italy.
Maria MarcheseMolecular Medicine, IRCCS Fondazione Stella Maris, Via dei Giacinti 2, 56028 Pisa, Italy.ORCID 0000-0002-0194-0702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of sources and spatiotemporal evolution of ictal bursts is critical for the mechanistic understanding of epilepsy and for the validation of anti-epileptic drugs. Zebrafish is a powerful vertebrate model representing an excellent compromise between system complexity and experimental accessibility. We performed the quantitative evaluation of the spatial recruitment of neuronal populations during physiological and pathological activity by combining local field potential (LFP) recordings with simultaneous 2-photon Ca

Indexed as

Electrophysiological PhenomenaMolecular ImagingPhotonsAction PotentialsAnimalsCalciumEpilepsyFemaleHumansMaleNeuronsPrincipal Component AnalysisStatistics as TopicTime FactorsValproic AcidZebrafishCalciumValproic Acidelectrophysiologyepilepsystatistical-based analysistwo-photon calcium imagingzebrafish

Identifiers

PMID32245158
PMCPMC7140665

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.