ArticleJournal of clinical medicine2020
Multifunctional Properties of Quercitrin-Coated Porous Ti-6Al-4V Implants for Orthopaedic Applications Assessed In Vitro.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Three-dimensional printed artificial vertebral body versus titanium mesh cage and nanohydroxyapatite/polyamide-66 cage in anterior cervical corpectomy and fusion: a retrospective cohort study with a minimum 5-year follow-up.Journal of orthopaedic surgery and research · 2026Observational
- Advanced Manufacturing of PLA Surgical Templates for Orbital Floor Geometry: Optimizing Fidelity and Surface Morphology via Variable Layer Height MEX 3D Printing.Materials (Basel, Switzerland) · 2026Article
- Antibacterial polyphenols for osteomyelitis treatment: from antibacterial mechanisms to biomaterial-based delivery.Frontiers in cell and developmental biology · 2026Review
- Nanotechnology in Osteogenesis and Inflammation Management: Metal-Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration.Biomedicines · 2025Review
- Functional hydrogel empowering 3D printing titanium alloys.Materials today. Bio · 2025Review
- Review
- Surface-modified titanium and titanium-based alloys for improved osteogenesis: A critical review.Heliyon · 2024Review
- Traditional Chinese medicine promotes bone regeneration in bone tissue engineering.Chinese medicine · 2022Review
- Porous construction and surface modification of titanium-based materials for osteogenesis: A review.Frontiers in bioengineering and biotechnology · 2022Review
- Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization.Frontiers in bioengineering and biotechnology · 2022Review
- Procedure Increasing the Accuracy of Modelling and the Manufacturing of Surgical Templates with the Use of 3D Printing Techniques, Applied in Planning the Procedures of Reconstruction of the Mandible.Journal of clinical medicine · 2021Article
- Trends in Managing Cardiac and Orthopaedic Device-Associated Infections by Using Therapeutic Biomaterials.Polymers · 2021Review
- Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
(1) One strategy to improve the outcome of orthopedic implants is to use porous implants with the addition of a coating with an antibacterial biomolecule. In this study, we aimed to produce and test the biocompatibility, the osteopromotive (both under normal conditions and under a bacterial challenge with lipopolysaccharide (LPS)) and antibacterial activities of a porous Ti-6Al-4V implant coated with the flavonoid quercitrin in vitro. (2) Porous Ti-6Al-4V implants were produced by 3D printing and further functionalized with quercitrin by wet chemistry. Implants were characterized in terms of porosity and mechanical testing, and the coating with quercitrin by fluorescence staining. Implant biocompatibility and bioactivity was tested using MC3T3-E1 preosteoblasts by analyzing cytotoxicity, cell adhesion, osteocalcin production, and alkaline phosphatase (ALP) activity under control and under bacterial challenging conditions using lipopolysaccharide (LPS). Finally, the antibacterial properties of the implants were studied using
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.