Evidence map›Paper›PMID 32245032›Full record

ArticleMolecules (Basel, Switzerland)2020

In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [

Cornelius K Donat, Henrik H Hansen, Hanne D Hansen, Ronnie C Mease, Andrew G Horti, Martin G Pomper, Elina T L'Estrade, Matthias M Herth, Dan Peters, Gitte M Knudsen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Assessment of [Biomolecules · 2025
    Article
  2. Review
  3. Evaluation of [Receptors (Basel, Switzerland) · 2025
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Development ofACS chemical neuroscience · 2022
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Cornelius K DonatNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Henrik H HansenNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Hanne D HansenNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.ORCID 0000-0001-5564-7627
Ronnie C MeaseRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Andrew G HortiRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Martin G PomperRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Elina T L'EstradeNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Matthias M HerthDepartment of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.
Dan PetersDanPET AB, 216 19 Malmö, Sweden.
Gitte M KnudsenNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Jens D MikkelsenNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Copenhagen University Hospital · DKJohns Hopkins University · USUniversity of Copenhagen · DKDanpet (Sweden) · SE

Funding

Augustinus Fonden xxxElsass Fonden xxxLundbeckfonden xxxStrategiske Forskningsråd COGNITO
6 · The paper itself

Abstract

The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and Alzheimer's disease, which makes it a relevant drug target. Development of selective radioligands is important for defining binding properties and occupancy of novel molecules targeting the receptor. We tested the in vitro binding properties of [

Indexed as

Fluorodeoxyglucose F18Iodine RadioisotopesRadioactive TracersRadiopharmaceuticalsalpha7 Nicotinic Acetylcholine ReceptorAnimalsAutoradiographyMolecular StructurePositron-Emission TomographyProtein BindingProtein MultimerizationSwineThiophenesalpha7 Nicotinic Acetylcholine ReceptordibenzothiopheneFluorodeoxyglucose F18Iodine-125Iodine RadioisotopesRadioactive TracersRadiopharmaceuticalsThiophenesalpha 7autoradiographynAChRnicotinic acetylcholine receptorsPET

Identifiers

PMID32245032
PMCPMC7144377
OpenAlexW3010720441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.