ArticleJournal of clinical medicine2020
Increased Amygdala Activations during the Emotional Experience of Death-Related Pictures in Complicated Grief: An fMRI Study.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Neural correlates of acute task-related stress in humans: a systematic review and coordinate-based ALE meta-analysis.Brain imaging and behavior · 2026Pooled it
- A Systematic Review of MRI Studies and the "Emotional paiN and social Disconnect (END)" Brain Model of Suicidal Behavior in Youth.Behavioural neurology · 2023Pooled it
- The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review.Psychiatry research. Neuroimaging · 2020Pooled it
- Disrupted Large-Scale Brain Network Connectivity in Prolonged Grief Disorder: Relationship With Grief-Related Avoidance, Yearning, and Intrusive Thoughts.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- The impact of death attitudes on death anxiety among nursing interns: a multicenter cross-sectional study.BMC palliative care · 2026Article
- Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Amygdala-Centered Emotional Processing in Prolonged Grief Disorder: Relationship With Clinical Symptomatology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- The effects of social loss and isolation on partner odor investigation and dopamine and oxytocin receptor expression in female prairie voles.Neuropharmacology · 2025Article
- Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers' brain and stress-coping behavior in the first week postpartum.Neuroscience applied · 2024Article
- Atrophy in the supramarginal gyrus associated with impaired cognitive inhibition in grieving Chinese Shidu parents.European journal of psychotraumatology · 2024Article
- Ventral striatal subregional dysfunction in late-life grief: Relationships with yearning and depressive symptoms.Journal of psychiatric research · 2022Article
- Interactions between thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Emerging experience with selected new categories in the ICD-11: complex PTSD, prolonged grief disorder, gaming disorder, and compulsive sexual behaviour disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Why do mothers never stop grieving for their deceased children? Enduring alterations of brain connectivity and function.Frontiers in human neuroscience · 2022Article
- Emotion regulation in prolonged grief disorder in later life: Protocol and rationale for a longitudinal neuroimaging study.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Complicated grief (CG) is associated with alterations in various components of emotional processing. The main aim of this study was to identify brain activations in individuals diagnosed with CG while they were observing positive, negative, and death-related pictures. The participants included 19 individuals with CG and 19 healthy non-bereaved (NB) individuals. Functional magnetic resonance imaging (fMRI) scans were obtained during an emotional experience task. The perception of death-related pictures differed between the CG group and the NB group, with a greater activation in the former of the amygdala, putamen, hypothalamus, middle frontal gyrus, and anterior cingulate cortex. Amygdala and putamen activations were significantly correlated with Texas Revised Inventory of Grief scores in the CG group, suggesting that the higher level of grief in this group was associated with a greater activation in both brain areas while watching death-related pictures. A significant interaction between image type and group was observed in the amygdala, midbrain, periaqueductal gray, cerebellum, and hippocampus, largely driven by the greater activation of these areas in the CG group when watching death-related pictures and the lower activation when watching positive-valence pictures. In this study, individuals with CG showed significantly distinct brain activations in response to different emotional images.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.