Evidence map›Paper›PMID 32244938›Full record

ArticleBiomedicines2020

Attenuation of Hyperoxic Lung Injury in Newborn Thioredoxin-1-Overexpressing Mice through the Suppression of Proinflammatory Cytokine mRNA Expression.

Nobuhiko Nagano, Kosuke Tanaka, Junichi Ozawa, Takaaki Watanabe, Fuyu Miyake, Shun Matsumura, Kohei Osada, Kikumi Matsuoka, Masanori Tamura, Fumihiko Namba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nobuhiko NaganoDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.ORCID 0000-0002-0890-1626
Kosuke TanakaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Junichi OzawaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Takaaki WatanabeDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Fuyu MiyakeDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Shun MatsumuraDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Kohei OsadaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Kikumi MatsuokaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Masanori TamuraDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.
Fumihiko NambaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350-8550, Japan.ORCID 0000-0001-6137-4477

Funding

Grants-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science 17K18156Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics 28-Y-6Ochiai Memorial Award Research Grant 27-1
6 · The paper itself

Abstract

The role of thioredoxin-1 (TRX), a small redox-active protein with antioxidant effects, during hyperoxic lung injury in newborns remains undetermined. We investigated TRX impact on hyperoxic lung injury in newborn TRX transgenic (TRX-Tg) and wildtype (WT) mice exposed to 21% or 95% O

Indexed as

antioxidant effectshyperoxic lung injurynewborn miceproinflammatory cytokine gene expressionthioredoxin-1

Identifiers

PMID32244938
PMCPMC7148529

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.