Evidence map›Paper›PMID 32244936›Full record

ReviewInternational journal of molecular sciences2020

Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease.

Pang Hung Wu, Hyeun Sung Kim, Il-Tae Jang

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07127380 (MID-MIS Trail Protocol - Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain), which is not on this map. Cited by 152 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 9 pooled it
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07127380 narecruitingnot on this mapstarted 2025, after this paper: background citation

MID-MIS Trail Protocol - Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain

TypeinterventionalSponsorCopernicus Memorial HospitalRan2025 to 2028Enrolled100ConditionsLower Back Pain Chronic, Lumbar Degenerative Disease, Lumbar Disc Degeneration, Degenerative Disc Disease(DDD)ArmsMidline Lumbar Interbody Fusion (MIDLIF), Minimally Invasive Transforaminal Lumbar Interbody Fusion (mini-TLIF)
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 9 syntheses or guidelines pooled it, 255 citations in OpenAlex.

  1. Pooled it
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  7. Artificial Intelligence and Computer Aided Diagnosis in Chronic Low Back Pain: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  10. Trial
  11. Trial
  12. Review
  13. Article
  14. Observational
  15. Article
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  18. Nationwide analysis of spinal surgery in Japan from 1994 to 2021.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  19. Article
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Pang Hung WuSpine Surgery, Nanoori Gangnam Hospital, Seoul 06048, Korea.
Hyeun Sung KimSpine Surgery, Nanoori Gangnam Hospital, Seoul 06048, Korea.ORCID 0000-0001-5361-5234
Il-Tae JangSpine Surgery, Nanoori Gangnam Hospital, Seoul 06048, Korea.
Wooridul Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With an aging population, there is a proportional increase in the prevalence of intervertebral disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and disability. With a high prevalence of asymptomatic intervertebral disc diseases, there is a need for accurate diagnosis, which is key to management. A thorough understanding of the pathophysiology and clinical manifestation aids in understanding the natural history of these conditions. Recent developments in radiological and biomarker investigations have potential to provide noninvasive alternatives to the gold standard, invasive discogram. There is a large volume of literature on the management of intervertebral disc diseases, which we categorized into five headings: (a) Relief of pain by conservative management, (b) restorative treatment by molecular therapy, (c) reconstructive treatment by percutaneous intervertebral disc techniques, (d) relieving compression and replacement surgery, and (e) rigid fusion surgery. This review article aims to provide an overview on various current diagnostic and treatment options and discuss the interplay between each arms of these scientific and treatment advancements, hence providing an outlook of their potential future developments and collaborations in the management of intervertebral disc diseases.

Indexed as

BiomarkersClinical Decision-MakingConservative TreatmentHumansIntervertebral Disc DegenerationIntervertebral Disc DisplacementReference StandardsBiomarkersdegenerative disc diseasegene therapyintervertebral discspinal decompressionspinal endoscopyspinal fusionspinal injectionspinal molecular therapyspine pain managementstem cells

Identifiers

PMID32244936
PMCPMC7139690
OpenAlexW3012168781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.