ArticleInternational journal of environmental research and public health2020
Nine-Year Nationwide Environmental Surveillance of Hepatitis E Virus in Urban Wastewaters in Italy (2011-2019).
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- A Systematic Review of Gastrointestinal and Respiratory Pathogen Detection in Wastewater in Africa, with Focus on Rwanda: Implications for Early Warning and Public Health Surveillance.Pathogens (Basel, Switzerland) · 2026Pooled it
- Hepatitis E Virus in Water Environments: A Systematic Review and Meta-analysis.Food and environmental virology · 2022Pooled it
- A capsid hinge region in European hepatitis E virus links mutations to genotype, virion surface properties, and environmental circulation.Applied and environmental microbiology · 2026Article
- Genetic insights into hepatitis E virus through environmental surveillance in Europe.One health (Amsterdam, Netherlands) · 2026Review
- First Detection of Hepatitis E Virus in Wastewater in Costa Rica.Food and environmental virology · 2026Article
- Hepatitis E in Wildlife: Emerging Threats to Human Health.Veterinary sciences · 2026Review
- Optimization of a Semi-nested PCR Protocol for Amplifying the Entire Spike Protein Region to Identify SARS-CoV-2 Variants in Wastewater.Food and environmental virology · 2026Article
- Trends and Challenges in the Detection and Environmental Surveillance of the Hepatitis E Virus.Microorganisms · 2025Review
- Eight Years of Norovirus Surveillance in Urban Wastewater: Insights from Next-Generation.Viruses · 2025Article
- Hepatitis E and Potential Public Health Implications from a One-Health Perspective: Special Focus on the European Wild Boar (Pathogens (Basel, Switzerland) · 2024Review
- Water-Based Epidemiological Investigation of Hepatitis E Virus in South Africa.Food and environmental virology · 2024Article
- Review
- Evidence of Circulation and Phylogenetic Analysis of Hepatitis E Virus (HEV) in Wild Boar in South-East Italy.Viruses · 2023Article
- Monkeypox outbreak: Wastewater and environmental surveillance perspective.The Science of the total environment · 2023Review
- Hepatitis E virus in pigs and the environment: An updated review of public health concerns.Narra J · 2022Review
- Prevalence and risk factors for hepatitis E virus infection in blood donors: a nationwide survey in Italy, 2017 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Article
- Wastewater surveillance for SARS-CoV-2 in a small coastal community: Effects of tourism on viral presence and variant identification among low prevalence populations.Environmental research · 2022Article
- SARS-CoV-2 concentrations in a wastewater collection system indicated potential COVID-19 hotspots at the zip code level.The Science of the total environment · 2021Article
- Co-occurring indicator pathogens for SARS-CoV-2: A review with emphasis on exposure rates and treatment technologies.Case studies in chemical and environmental engineering · 2021Article
- Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis E virus (HEV) is an emerging causative agent of acute hepatitis worldwide. To provide insights into the epidemiology of HEV in Italy, a large-scale investigation was conducted into urban sewage over nine years (2011-2019), collecting 1374 sewage samples from 48 wastewater treatment plants located in all the 20 regions of Italy. Broadly reactive primers targeting the ORF1 and ORF2 regions were used for the detection and typing of HEV, followed by Sanger and next generation sequencing (NGS). Real-time RT-qPCR was also used to attempt quantification of positive samples. HEV RNA detection occurred in 74 urban sewage samples (5.4%), with a statistically significant higher frequency (7.1%) in central Italy. Fifty-six samples were characterized as G3 strains and 18 as G1. While the detection of G3 strains occurred in all the surveillance period, G1 strains were mainly detected in 2011-2012, and never in 2017-2019. Typing was achieved in 2 samples (3f subtype). Viral concentrations in quantifiable samples ranged from 1.2 × 10
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