Evidence map›Paper›PMID 32244880›Full record

ReviewNutrients2020

Influence of Maternal Milk on the Neonatal Intestinal Microbiome.

Kathyayini P Gopalakrishna, Timothy W Hand

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Trial
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. A Feline Milk-DrivedMicroorganisms · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. The Prophylactic Protection ofMicroorganisms · 2025
    Article
  19. Single-cell quantification of the microbiota by flow cytometry: MicFLY.bioRxiv : the preprint server for biology · 2025
    Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kathyayini P GopalakrishnaR. K. Mellon Institute for Pediatric Research, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15217, USA.
Timothy W HandR. K. Mellon Institute for Pediatric Research, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15217, USA.ORCID 0000-0002-2684-9462
University of Pittsburgh · US

Funding

Mechanisms of maternal Immunoglobulin A control over the neonatal microbiota and the development of Necrotizing Enterocolitis.R01DK120697 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy Wesley Hand · 2020 to 2026
$3.6M
NIH HHS R01DK120697
6 · The paper itself

Abstract

The intestinal microbiome plays an important role in maintaining health throughout life. The microbiota develops progressively after birth and is influenced by many factors, including the mode of delivery, antibiotics, and diet. Maternal milk is critically important to the development of the neonatal intestinal microbiota. Different bioactive components of milk, such as human milk oligosaccharides, lactoferrin, and secretory immunoglobulins, modify the composition of the neonatal microbiota. In this article, we review the role of each of these maternal milk-derived bioactive factors on the microbiota and how this modulation of intestinal bacteria shapes health, and disease.

Indexed as

Breast FeedingGastrointestinal MicrobiomeMilk, HumanAnti-Bacterial AgentsBiodiversityFemaleHumansImmunoglobulin A, SecretoryInfant, NewbornLactoferrinMilk ProteinsNutrientsOligosaccharidesAnti-Bacterial AgentsImmunoglobulin A, SecretoryLactoferrinmilk-derived factorMilk ProteinsNutrientsOligosaccharidesbreast milkhuman milk oligosaccharideslactoferrinmaternal milkneonatal microbiomesecretory IgA

Identifiers

PMID32244880
PMCPMC7146310
OpenAlexW3012011506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.