Evidence map›Paper›PMID 32244773›Full record

ArticleMaterials (Basel, Switzerland)2020

Preparation, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Cellulose Aerogel.

Lili Qin, Xinyu Zhao, Yiwei He, Hongqiang Wang, Hanjing Wei, Qiong Zhu, Ting Zhang, Yao Qin, Ai Du

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lili QinSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Xinyu ZhaoSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Yiwei HeSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Hongqiang WangSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, China.ORCID 0000-0001-6036-9756
Hanjing WeiSchool of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Qiong ZhuSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, China.
Ting ZhangSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, China.
Yao QinSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Ai DuSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, China.ORCID 0000-0002-6113-6185
Tongji University · CN

Funding

National Key Research and Development Program of China 2017YFA0204600National Natural Science Foundation of China 31771313
6 · The paper itself

Abstract

Resveratrol is a natural active ingredient found in plants, which is a polyphenolic compound and has a variety of pharmaceutical uses. Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) was prepared using a freeze-drying method, employing high speed homogenization followed by rapid freezing with liquid nitrogen. RLTAs were designed at varying drug-cellulose aerogel ratios (1:2, 2:3, 3:2, and 2:1). It could be seen via scanning electron microscopy (SEM) that Res integrated into TEMPO-oxidized cellulose (TC) at different ratios, which changed its aggregation state and turned it into a short rod-like structure. Fourier transform infrared (FTIR) spectra confirmed that the RLTAs had the characteristic peaks of TC and Res. In addition, X-ray diffraction (XRD) demonstrated that the grain size of RLTA was obviously smaller than that of pure Res. RLTAs also had excellent stability in both simulated gastric fluid and phosphate buffer solution. The drug release rate was initially completed within 5 h under a loading rate of 30.7 wt%. The results of an MTT assay showed the low toxicity and good biocompatibility of the RLTAs. TC aerogel could be a promising drug carrier that may be widely used in designing and preparing novel biomedicine.

Indexed as

aerogeldrug carrierresveratrolTEMPO-oxidized cellulose

Identifiers

PMID32244773
PMCPMC7178353
OpenAlexW3014558423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.