Evidence map›Paper›PMID 32244749›Full record

Observational studyInternational journal of molecular sciences2020

Exploratory Analysis of Circulating miRNA Signatures in Atrial Fibrillation Patients Determining Potential Biomarkers to Support Decision-Making in Anticoagulation and Catheter Ablation.

Naoki Kiyosawa, Kenji Watanabe, Yoshiyuki Morishima, Takeshi Yamashita, Naoharu Yagi, Takuto Arita, Takayuki Otsuka, Shinya Suzuki

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  16. Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Naoki KiyosawaSpecialty Medicine Research Laboratories I, Daiichi Sankyo Co., Ltd., Tokyo 140-0005, Japan.
Kenji WatanabeBiomarker & Translational Research Department, Daiichi Sankyo Co., Ltd., Tokyo 140-0005, Japan.ORCID 0000-0002-0301-8906
Yoshiyuki MorishimaMedical Science Department, Daiichi Sankyo Co., Ltd., Tokyo 103-8426, Japan.
Takeshi YamashitaDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo 106-0031, Japan.ORCID 0000-0002-2544-8464
Naoharu YagiDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo 106-0031, Japan.
Takuto AritaDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo 106-0031, Japan.
Takayuki OtsukaDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo 106-0031, Japan.
Shinya SuzukiDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo 106-0031, Japan.ORCID 0000-0002-4769-5925
Cardiovascular Institute Hospital · JPDaiichi-Sankyo (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel biomarkers are desired to improve risk management for patients with atrial fibrillation (AF). We measured 179 plasma miRNAs in 83 AF patients using multiplex qRT-PCR. Plasma levels of eight (i.e., hsa-miR-22-3p, hsa-miR-128-3p, hsa-miR-130a-3p, hsa-miR-140-5p, hsa-miR-143-3p, hsa-miR-148b-3p, hsa-miR-497-5p, hsa-miR-652-3p) and three (i.e., hsa-miR-144-5p, hsa-miR-192-5p, hsa-miR-194-5p) miRNAs showed positive and negative correlations with CHA

Indexed as

AgedAged, 80 and overAnticoagulantsAtrial FibrillationBiomarkersCatheter AblationCirculating MicroRNADecision MakingFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansMaleMiddle AgedPyridinesAnticoagulantsBiomarkersCirculating MicroRNAedoxabanPyridinesThiazolesatrial fibrillationbiomarkercatheter ablationcirculating miRNAfibrosisstroke risk

Identifiers

PMID32244749
PMCPMC7178177
OpenAlexW3014195318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.