Evidence map›Paper›PMID 32244718›Full record

ReviewPharmaceuticals (Basel, Switzerland)2020

The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs.

Simona Federica Spampinato, Grazia Ilaria Caruso, Rocco De Pasquale, Maria Angela Sortino, Sara Merlo

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 6 pooled it
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 6 syntheses or guidelines pooled it, 428 citations in OpenAlex.

  1. Pooled it
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  7. Trial
  8. Article
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  11. Article
  12. Observational
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    Review
  19. Photobiomodulation at 830 nm with 5 J/cmLasers in medical science · 2026
    Article
  20. Review

132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Simona Federica SpampinatoDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology University of Catania, 95123 Catania, Italy.ORCID 0000-0001-7564-1986
Grazia Ilaria CarusoDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology University of Catania, 95123 Catania, Italy.
Rocco De PasqualeDepartment of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy.
Maria Angela SortinoDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology University of Catania, 95123 Catania, Italy.ORCID 0000-0002-2734-1521
Sara MerloDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology University of Catania, 95123 Catania, Italy.ORCID 0000-0002-6558-9800
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds often occur in patients with diabetes mellitus due to the impairment of wound healing. This has negative consequences for both the patient and the medical system and considering the growing prevalence of diabetes, it will be a significant medical, social, and economic burden in the near future. Hence, the need for therapeutic alternatives to the current available treatments that, although various, do not guarantee a rapid and definite reparative process, appears necessary. We here analyzed current treatments for wound healing, but mainly focused the attention on few classes of drugs that are already in the market with different indications, but that have shown in preclinical and few clinical trials the potentiality to be used in the treatment of impaired wound healing. In particular, repurposing of the antiglycemic agents dipeptidylpeptidase 4 (DPP4) inhibitors and metformin, but also, statins and phenyotin have been analyzed. All show encouraging results in the treatment of chronic wounds, but additional, well designed studies are needed to allow these drugs access to the clinics in the therapy of impaired wound healing.

Indexed as

diabetic foot ulcerDPP4 inhibitordrug repurposingmetforminphenytoinstatinswound closure

Identifiers

PMID32244718
PMCPMC7243111
OpenAlexW3014551294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.