Evidence map›Paper›PMID 32244707›Full record

ReviewMicroorganisms2020

Spheres of Influence: Insights into

Smriti Verma, Stefania Senger, Bobby J Cherayil, Christina S Faherty

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Concurrent emergencies: overlappingFrontiers in public health · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Cross-Talk Between the Intestinal Epithelium andFrontiers in microbiology · 2022
    Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Smriti VermaMucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown Navy Yard, Boston, 02129 MA, USA.ORCID 0000-0002-3760-8090
Stefania SengerMucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown Navy Yard, Boston, 02129 MA, USA.
Bobby J CherayilMucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown Navy Yard, Boston, 02129 MA, USA.ORCID 0000-0002-6602-3374
Christina S FahertyMucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown Navy Yard, Boston, 02129 MA, USA.ORCID 0000-0002-3200-161X
Harvard University · US

Funding

Cross-talk between iron metabolism and intestinal inflammationR01AI089700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHERAYIL, BOBBY JOSEPH · 2011 to 2020
$4.4M
Microbiome-derived Metabolites Linked to Celiac Disease Onset in Infants at RiskR01DK104344 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FASANO, ALESSIO · 2016 to 2020
$3.4M
The mechanism of Shigella flexneri adherence during the early infection processK22AI104755 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FAHERTY, CHRISTINA S · 2014 to 2015
$270k
MGH ECOR Interim 657 Support Fund 2020A003037MGH ECOR Interim Support Fund 2019A004390National Institute of Allergy and Infectious Diseases K22AI104755NIAID NIH HHS K22 AI104755NIAID NIH HHS R01 AI089700NIDDK NIH HHS RO1DK104344-01A1NIH HHS R01AI089700
6 · The paper itself

Abstract

The molecular complexity of host-pathogen interactions remains poorly understood in many infectious diseases, particularly in humans due to the limited availability of reliable and specific experimental models. To bridge the gap between classical two-dimensional culture systems, which often involve transformed cell lines that may not have all the physiologic properties of primary cells, and in vivo animal studies, researchers have developed the organoid model system. Organoids are complex three-dimensional structures that are generated in vitro from primary cells and can recapitulate key in vivo properties of an organ such as structural organization, multicellularity, and function. In this review, we discuss how organoids have been deployed in exploring

Indexed as

enteroidshost-pathogen interactionsinfectious diseasesmodel systemsorganoidsorganotypic culture systemSalmonella

Identifiers

PMID32244707
PMCPMC7232497
OpenAlexW3014222203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.