Evidence map›Paper›PMID 32244635›Full record

ArticleMolecules (Basel, Switzerland)2020

Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer's Disease.

Priya Kashyap, Vivekanandan Kalaiselvan, Robin Kumar, Suresh Kumar

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  6. Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Frontiers in pharmacology · 2023
    Article
  13. Review
  14. Review
  15. Review
  16. Identification of Potential Poly (ADP-Ribose) Polymerase-1 Inhibitors Derived fromEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Priya KashyapUniversity School of Biotechnology, Guru Gobind Singh Indraprastha University, Dwarka, Sector 16C, New Delhi 110075, India.
Vivekanandan KalaiselvanIndian Pharmacopoeia Commission, Pharmacovigilance Laboratory, Sector 23, Raj Nagar, Ghaziabad, Uttar Pradesh-201002, India.
Robin KumarIndian Pharmacopoeia Commission, Pharmacovigilance Laboratory, Sector 23, Raj Nagar, Ghaziabad, Uttar Pradesh-201002, India.
Suresh KumarUniversity School of Biotechnology, Guru Gobind Singh Indraprastha University, Dwarka, Sector 16C, New Delhi 110075, India.
Guru Gobind Singh Indraprastha University · IN

Funding

GGS Indraprastha University FRGS18-19
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial disorder characterized by exponential loss of memory and cognitive deficit involving several disease modifying targets (amyloid beta, beta-secretase, monoaminoxidase-B, and cholinesterase). The present study explores multi-target directed ligand approach using secondary metabolite reserpine (RES) and ajmalicine (AJM) obtained from

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCell SurvivalCholinesterase InhibitorsChromatography, High Pressure LiquidDose-Response Relationship, DrugHumansIndole AlkaloidsLigandsPC12 CellsPhytochemicalsPlant ExtractsProtein AggregatesProtein Aggregation, PathologicalRatsAmyloid beta-PeptidesCholinesterase InhibitorsIndole AlkaloidsLigandsPhytochemicalsPlant ExtractsProtein AggregatesraubasineReserpineSecologanin Tryptamine AlkaloidsajmalicineAlzheimer’s diseaseAβBACE-1MAO-Bmolecular dockingmulti target directed ligandrauwolfia serpentinareserpine

Identifiers

PMID32244635
PMCPMC7180484
OpenAlexW3014260299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.