SynthesisInternational journal of environmental research and public health2020
A Specific Inflammatory Profile Underlying Suicide Risk? Systematic Review of the Main Literature Findings.
Synthesis in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 7 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
96 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Risk of suicidal behaviors following sport-related and non-sport-related concussion: a systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Gray Matter Alterations in Panic Disorder: A Voxel-Wise Meta-Analysis.Psychiatry and clinical psychopharmacology · 2023Pooled it
- Evidence for the biopsychosocial model of suicide: a review of whole person modeling studies using machine learning.Frontiers in psychiatry · 2023Pooled it
- Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Increased C-reactive protein concentration and suicidal behavior in people with psychiatric disorders: A systematic review and meta-analysis.Acta psychiatrica Scandinavica · 2021Pooled it
- Clinical efficacy of escitalopram combined with botulinum toxin A in patients with generalized anxiety disorder and comorbid headache.Psychopharmacology · 2023Trial
- Inflammation and treatment strategies for suicidal behavior.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2026Review
- Elevated serum calprotectin levels in major depressive disorder: no evidence of association with S100A9 rs3014866 polymorphism.BMC psychiatry · 2026Article
- Psychotic Symptoms Following Subthalamic DBS in Parkinson's Disease: Three Clinical Cases and Literature Review.Clinical case reports · 2026Article
- Low 5HTJournal of neurochemistry · 2026Review
- Efficacy of Sertraline Combined With Intestinal Microecological Therapy in Adolescents With Moderate Depression and Suicidal Ideation and Its Effects on Serum Inflammatory Factors.Actas espanolas de psiquiatria · 2026Article
- Vitamin D deficiency, depression severity, and suicide risk: evidence from patients with major depressive disorder.Turkish journal of medical sciences · 2026Article
- Association between Suicidal Ideation and Immune Parameters in First-episode Patients with Schizophrenia.Current neuropharmacology · 2026Article
- The relationship between suicidal behavior and hematological inflammatory parameters: a retrospective cohort study.Frontiers in psychiatry · 2026Article
- Biomarkers Identifying Tendency to Suicide (BITS): detection of biomarkers in adolescents with suicidal ideation or suicidal behavior for early prevention or intervention. A prospective cohort study.Frontiers in human neuroscience · 2026Article
- Whole Blood Transcriptome Analysis in Female Adolescents With Depression Accompanied by Nonsuicidal Self-Injury and Suicide Attempt.Depression and anxiety · 2026Observational
- Suicide attempt predictors among adolescents exhibiting non-suicidal self-injury: A six-week follow-up open study.World journal of psychiatry · 2025Article
- Assessing the relationship between suicidality and inflammatory biomarkers: C-reactive protein/albumin and neutrophil/albumin ratios in an inpatient setting.BMC psychiatry · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consistent evidence indicates the association between inflammatory markers and suicidal behavior. The burden related to immunological differences have been widely documented in both major affective disorders and suicidal behavior. Importantly, abnormally elevated pro-inflammatory cytokines levels have been reported to correlate with suicidal behavior but whether and to what extent specific inflammatory cytokines abnormalities may contribute to our understanding of the complex pathophysiology of suicide is unknown. The present manuscript aimed to systematically review the current literature about the role of pro-inflammatory cytokines in suicidal behavior. Most studies showed a link between abnormally higher interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF), kynurenic acid (KYN), and lower IL-2, IL-4, and interferon (IFN)-γ levels in specific brain regions and suicidal behavior. Unfortunately, most studies are not able to exclude the exact contribution of major depressive disorder (MDD) as a mediator/moderator of the link between inflammatory cytokines abnormalities and suicidal behavior. The association between suicidal patients (both suicide attempters or those with suicidal ideation) and the altered immune system was documented by most studies, but this does not reflect the existence of a specific causal link. Additional studies are needed to clarify the immune pathways underlying suicidal behavior.
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