Evidence map›Paper›PMID 32244562›Full record

ArticleInternational journal of molecular sciences2020

Identification and Regulation of Interleukin-17 (IL-17) Family Ligands in the Teleost Fish European Sea Bass.

Carmen González-Fernández, Elena Chaves-Pozo, Alberto Cuesta

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Association ofInternational journal of fertility & sterility · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Carmen González-FernándezImmunobiology for Aquaculture, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
Elena Chaves-PozoOceanographic Centre of Murcia, Spanish Institute of Oceanography (IEO), Carretera de la Azohía s/n., Puerto de Mazarrón, 30860 Murcia, Spain.ORCID 0000-0003-4030-1273
Alberto CuestaImmunobiology for Aquaculture, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.ORCID 0000-0002-0906-7995
Universidad de Murcia · ESInstituto Español de Oceanografía · ES

Funding

Fundación Séneca 19883/GERM/15Instituto Español de Oceanografía NODAMEDMinisterio de Economía y Competitividad AGL2013-43588-P and AGL2016-74866-C3-1-R
6 · The paper itself

Abstract

Interleukin-17 (IL-17) cytokine comprises a family of six ligands in mammals with proinflammatory functions, having an important role in autoimmune disorders and against bacterial, viral, and fungal pathogens. While IL-17A and IL-17F ligands are mainly produced by Th cells (Th17 cells), the rest of the ligands are expressed by other immune and non-immune cells and have different functions. The identification of IL-17 ligands in fish has revealed the presence of six members, counterparts to mammalian ones, and a teleost-specific form, the fish IL-17N. However, tissue distribution, the regulation of gene expression, and scarce bioactivity assays point to similar functions compared to mammalian ones, though this yet to be investigated and confirmed. Thus, we have identified seven IL-17 ligands in the teleost European sea bass (

Indexed as

PhylogenyAmino Acid SequenceAnimalsBassCytokinesFish DiseasesGene Expression RegulationImmunity, InnateInterleukin-17LigandsTh17 CellsT-LymphocytesUp-RegulationCytokinesInterleukin-17Ligandsfishimmunityinterleukin 17 (IL-17)nodavirus (NNV)PAMPsTh17 cells

Identifiers

PMID32244562
PMCPMC7178287
OpenAlexW3014466146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.