Evidence map›Paper›PMID 32244514›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives.

Ana T P C Gomes, Rosa Fernandes, Carlos F Ribeiro, João P C Tomé, Maria G P M S Neves, Fernando de C da Silva, Vítor F Ferreira, José A S Cavaleiro

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Anticancer Activity of Ether Derivatives of Chrysin.Molecules (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ana T P C GomesLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-3201-0081
Rosa FernandesCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Carlos F RibeiroCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-9707-4895
João P C ToméCQE, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.
Maria G P M S NevesLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-7953-8166
Fernando de C da SilvaDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ 24020-150, Brazil.ORCID 0000-0002-2042-3778
Vítor F FerreiraDepartamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ 24241-000, Brazil.ORCID 0000-0002-2166-766X
José A S CavaleiroLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-5495-5126
Rede de Química e Tecnologia · PTUniversidade Federal Fluminense · BRUniversity of Coimbra · PTUniversity of Lisbon · PT

Funding

Centro 2020 Regional Operational Programme CENTRO-01-0145-FEDER-000012Compete-FEDER POCI-01-0145-FEDER-007440Fundação para a Ciência e Tecnolgia FCT UID/QUI/00062/2013Fundação para a Ciência e Tecnologia FCT UID/QUI/00062/2019Fundação para a Ciência e Tecnologia SFRH/BPD/79521/2011Fundação para a Ciência e Tecnologia TDC/QEQQOR/1273/2012Fundação para a Ciência e Tecnologia UIDB/00100/2020Fundação para a Ciência e Tecnologia UIDB/50006/2020Fundação para a Ciência e Tecnologia UID/NEU/04539/2019
6 · The paper itself

Abstract

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR

Indexed as

AnimalsAntineoplastic AgentsChemistry Techniques, SyntheticHumansMicellesPhotochemotherapyPhotosensitizing AgentsPorphyrinsPovidoneTriazolesAntineoplastic AgentsMicellesPhotosensitizing AgentsPorphyrinsPovidoneTriazoleshuman bladder cancer cellshuman retinal pigment epithelial cellsphotodynamic therapypolyvinylpyrrolidoneporphyrintriazole

Identifiers

PMID32244514
PMCPMC7180931
OpenAlexW3014366001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.