Evidence map›Paper›PMID 32244512›Full record

ArticleMolecules (Basel, Switzerland)2020

Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity.

Lena Keller, Jair L Siqueira-Neto, Julia M Souza, Korina Eribez, Gregory M LaMonte, Jennifer E Smith, William H Gerwick

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

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  10. New Halogenated Compounds fromMolecules (Basel, Switzerland) · 2022
    Article
  11. Total Synthesis of (-)-Bastimolide A: A Showcase for Type I Anion Relay Chemistry.Angewandte Chemie (International ed. in English) · 2022
    Article
  12. Review
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lena KellerCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, USA.
Jair L Siqueira-NetoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Julia M SouzaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Korina EribezDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Gregory M LaMonteNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP 14404-600, Brazil.
Jennifer E SmithMarine Biology Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, USA.
William H GerwickCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, USA.
Scripps Institution of Oceanography · USUniversidade de Franca · BRUniversity of California San Diego · US

Funding

Deutsche Forschungsgemeinschaft KE 2172/3-1Foundation for the National Institutes of Health GM107550
6 · The paper itself

Abstract

Marine Cyanobacteria (blue-green algae) have been shown to possess an enormous potential to produce structurally diverse natural products that exhibit a broad spectrum of potent biological activities, including cytotoxic, antifungal, antiparasitic, antiviral, and antibacterial activities. Here, we report the isolation and structure determination of palstimolide A, a complex polyhydroxy macrolide with a 40-membered ring that was isolated from a tropical marine cyanobacterium collected at Palmyra Atoll. NMR-guided fractionation in combination with MS

Indexed as

AntimalarialsAquatic OrganismsCyanobacteriaMacrolidesMagnetic Resonance SpectroscopyMolecular StructureParasitic Sensitivity TestsStructure-Activity RelationshipAntimalarialsMacrolidesantimalarial agentscyanobacterialeishmaniosismacrolidemalarianatural products

Identifiers

PMID32244512
PMCPMC7180531
OpenAlexW3014562992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.