Evidence map›Paper›PMID 32244489›Full record

ArticleInternational journal of molecular sciences2020

Inhibition of Proinflammatory Enzymes and Attenuation of IL-6 in LPS-Challenged RAW 264.7 Macrophages Substantiates the Ethnomedicinal Use of the Herbal Drug

Rungcharn Suksungworn, Paula B Andrade, Andreia P Oliveira, Patrícia Valentão, Sutsawat Duangsrisai, Nelson G M Gomes

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecules (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. An integratedFrontiers in pharmacology · 2023
    Article
  7. Haskap Berry Leaves (Nutrients · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rungcharn SuksungwornDepartment of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wang Road, Chatuchak, Bangkok 10900, Thailand.
Paula B AndradeREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
Andreia P OliveiraREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
Patrícia ValentãoREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
Sutsawat DuangsrisaiDepartment of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wang Road, Chatuchak, Bangkok 10900, Thailand.
Nelson G M GomesREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
Universidade do Porto · PTKasetsart University · TH

Funding

Fundação para a Ciência e a Tecnologia UIDB/50006/2020Interreg project 0377_IBERPHENOL_6_EResearch and Innovation of Graduate study Strategy of the National Research Council of Thailand (NRCT) The Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission
6 · The paper itself

Abstract

Commonly used to treat skin injuries in Asia, several Homalium spp. have been found to promote skin regeneration and wound healing. While ethnobotanical surveys report the use of H. bhamoense trunk bark as a wound salve, there are no studies covering bioactive properties. As impaired cutaneous healing is characterized by excessive inflammation, a series of inflammatory mediators involved in wound healing were targeted with a methanol extract obtained from

Indexed as

AnimalsAnti-Inflammatory AgentsArachidonate 5-LipoxygenaseCell SurvivalCytokinesHerbal MedicineHyaluronoglucosaminidaseHydroxybenzoatesInflammation MediatorsInhibitory Concentration 50Interleukin-6KeratinocytesLipopolysaccharidesMacrophagesMedicine, TraditionalMiceAnti-Inflammatory AgentsArachidonate 5-LipoxygenaseCytokinesHyaluronoglucosaminidaseHydroxybenzoatesInflammation MediatorsInterleukin-6LipopolysaccharidesNitric Oxidephenolic acidPlant ExtractsTumor Necrosis Factor-alphacytokinesHomalium tomentosumhyaluronaninterleukinsmethyl ellagic acidpolyphenolstraditional medicine

Identifiers

PMID32244489
PMCPMC7178040
OpenAlexW3014131483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.