Evidence map›Paper›PMID 32244444›Full record

ArticleMolecules (Basel, Switzerland)2020

Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of Their in vitro Antiproliferative Effects.

Kinga Judit Fodor, Dániel Hutai, Tamás Jernei, Angéla Takács, Zsófia Szász, Máté Sulyok-Eiler, Veronika Harmat, Rita Oláh Szabó, Gitta Schlosser, Ferenc Hudecz and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kinga Judit FodorDepartment of Organic Chemistry, Eötvös Loránd University (ELTE) Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Dániel HutaiDepartment of Organic Chemistry, Eötvös Loránd University (ELTE) Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Tamás JerneiMTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Angéla TakácsDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Zsófia SzászDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Máté Sulyok-EilerLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Veronika HarmatLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Rita Oláh SzabóMTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Gitta SchlosserMTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Ferenc HudeczDepartment of Organic Chemistry, Eötvös Loránd University (ELTE) Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
László KőhidaiDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Antal CsámpaiDepartment of Organic Chemistry, Eötvös Loránd University (ELTE) Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.

Funding

European Union and the State of Hungary, co-financed by the European Regional Development Fund VEKOP-2.3.3-15-2017-00018European Union and the State of Hungary, co-financed by the European Regional Development Fund VEKOP-2.3.3-15-2017-00020Hungarian Scientific Research Fund OTKA K_129037National Research, Development and Innovation Office, Hungary NVKP_16-1-2016-0036
6 · The paper itself

Abstract

Use of a Pictet-Spengler reaction of tryptamine and l-tryptophan methyl ester and subsequent reduction of the nitro group followed by further cyclocondensation with aryl aldehydes and formyl-substituted carboxylic acids, including ferrocene-based components, furnished a series of diastereomeric 6-aryl-substituted 5,6,8,9,14,14b-hexahydroindolo[2',3':3,4]pyrido[1-

Indexed as

Antineoplastic AgentsCarbolinesCell Line, TumorChemistry Techniques, SyntheticDensity Functional TheoryFerrous CompoundsHumansMetallocenesModels, TheoreticalMolecular ConformationMolecular StructureSpectrum AnalysisStructure-Activity RelationshipAntineoplastic AgentsCarbolinesferroceneFerrous CompoundsMetallocenesconformationcytotoxic activityDFT calculationsdiastereoselectivityferroceneNMR spectroscopyorganic synthesisstructure-activity relationshipsX-ray diffractionβ-carboline

Identifiers

PMID32244444
PMCPMC7181298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.