Evidence map›Paper›PMID 32244398›Full record

ArticleInternational journal of molecular sciences2020

Tie-2 Cre-Mediated Deficiency of Extracellular Signal-Regulated Kinase 2 Potentiates Experimental Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Neonatal Mice.

Renuka T Menon, Amrit Kumar Shrestha, Roberto Barrios, Corey Reynolds, Binoy Shivanna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Renuka T MenonSection of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Amrit Kumar ShresthaSection of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Roberto BarriosDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Corey ReynoldsMouse Phenotyping Core, Baylor College of Medicine, Houston, TX 77030, USA.
Binoy ShivannaSection of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · USMethodist Hospital · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Consortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0M
Mechanistic Roles of Adrenomedullin and its Signaling Receptors in Experimental Bronchopulmonary Dysplasia and Pulmonary HypertensionR01HL139594 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI SHIVANNA, BINOY · 2018 to 2022
$2.0M
NHGRI NIH HHS U54 HG006348NHLBI NIH HHS R01 HL139594NIDDK NIH HHS P30 DK056338NIH HHS HL139594, P30DK056338, and U54HG006348
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) is a significant lung morbidity of infants, and disrupted lung angiogenesis is a hallmark of this disease. We observed that extracellular signal-regulated kinases (ERK) 1/2 support angiogenesis in vitro, and hyperoxia activates ERK1/2 in fetal human pulmonary microvascular endothelial cells (HPMECs) and in neonatal murine lungs; however, their role in experimental BPD and PH is unknown. Therefore, we hypothesized that

Indexed as

AnimalsAnimals, NewbornBronchopulmonary DysplasiaEndothelial CellsHumansHyperoxiaHypertension, PulmonaryIntegrasesLungMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PneumoniaReceptor, TIE-2Cre recombinaseIntegrasesMAPK1 protein, humanMapk1 protein, mouseMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Receptor, TIE-2Tek protein, mousebronchopulmonary dysplasiaextracellular signal-regulated kinase 2HPMECshyperoxiapulmonary hypertension

Identifiers

PMID32244398
PMCPMC7177249
OpenAlexW3014824471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.