Evidence map›Paper›PMID 32244348›Full record

ArticleInternational journal of molecular sciences2020

Cytotoxic Mechanism of Excess Polyamines Functions through Translational Repression of Specific Proteins Encoded by Polyamine Modulon.

Akihiko Sakamoto, Junpei Sahara, Gota Kawai, Kaneyoshi Yamamoto, Akira Ishihama, Takeshi Uemura, Kazuei Igarashi, Keiko Kashiwagi, Yusuke Terui

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. An extragenic fix for a broken enzyme.Microbiology (Reading, England) · 2026
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  6. Metabolomic profiling ofmSystems · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Akihiko SakamotoFaculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.
Junpei SaharaFaculty of Advanced Engineering, Chiba Institute of Technology, Chiba 275-0016, Japan.
Gota KawaiFaculty of Advanced Engineering, Chiba Institute of Technology, Chiba 275-0016, Japan.ORCID 0000-0003-1480-2840
Kaneyoshi YamamotoDepartment of Frontier Bioscience, Hosei University, Tokyo 184-8584, Japan.ORCID 0000-0003-0696-8939
Akira IshihamaDepartment of Frontier Bioscience, Hosei University, Tokyo 184-8584, Japan.ORCID 0000-0002-6339-9042
Takeshi UemuraAmine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba 260-0856, Japan.
Kazuei IgarashiAmine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba 260-0856, Japan.
Keiko KashiwagiFaculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.
Yusuke TeruiFaculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.
Chiba Institute of Science · JPChiba Institute of Technology · JPChiba University · JPHosei University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive accumulation of polyamines causes cytotoxicity, including inhibition of cell growth and a decrease in viability. We investigated the mechanism of cytotoxicity caused by spermidine accumulation under various conditions using an

Indexed as

AcetyltransferasesCodon, InitiatorDiamine N-AcetyltransferaseEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialMicrobial ViabilityPolyaminesProtein BiosynthesisProtein Processing, Post-TranslationalRibosomesRNA, MessengerSpermidineTranscription FactorsTrimebutineAcetyltransferasesCodon, InitiatorDiamine N-AcetyltransferaseEscherichia coli ProteinsPolyaminesRNA, MessengerSpermidineTranscription FactorsTrimebutinecell growthcell viabilitycytotoxicitypolyamine modulonpolyaminesspermidine

Identifiers

PMID32244348
PMCPMC7177335
OpenAlexW3014989788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.