ReviewMedicina (Kaunas, Lithuania)2020
Developmental Dysplasia of the Hip: A Review of Etiopathogenesis, Risk Factors, and Genetic Aspects.
Review in Medicina (Kaunas, Lithuania), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05822700 (Outcome Of Using Transfixing Hip K Wire ln Developmental Dysplasia Of Hip With Hypoplastic Head And Severe Generalised Ligamentous Laxity), which is not on this map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcome Of Using Transfixing Hip K Wire ln Developmental Dysplasia Of Hip With Hypoplastic Head And Severe Generalised Ligamentous Laxity
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Clinical efficacy of robot-assisted total hip arthroplasty for developmental dysplasia of the hip: A meta-analysis.Joint diseases and related surgery · 2026Pooled it
- Incidence, Prevalence, Risk Factors, and Clinical Treatment for Children with Developmental Dysplasia of the Hip in Saudi Arabia. A Systematic Review.Journal of epidemiology and global health · 2024Pooled it
- A thorough analysis of data on the correlation between COL9A1 polymorphisms and the susceptibility to congenital talipes equinovarus: a meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Prevalence of developmental dysplasia of the hip (DDH) in infants: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- A straightforward inexpensive method for hip cast immobilization in infants and children.Annals of medicine · 2026Article
- A historical journey through developmental dysplasia of the hip (DDH): from prehistoric evidence to the rise of modern diagnostic and therapeutic concepts.International orthopaedics · 2026Review
- Heterogeneity of the prevalence of congenital hip dislocation in Europe.World journal of pediatrics : WJP · 2026Article
- Single-cell RNA sequencing reveals extensive fibrotic remodeling and pathogenic chondrocyte subpopulations in developmental dysplasia of the hip.Translational pediatrics · 2026Article
- [Hip disorders in children and adolescents-an overview].Orthopadie (Heidelberg, Germany) · 2026Review
- DUSP26: Unveiling a critical molecular mediator and therapeutic target in developmental dysplasia of the hip‑associated secondary osteoarthritis.International journal of molecular medicine · 2026Article
- Analysis of LRP1 gene mutation in developmental dysplasia of the hip: a case series.BMC medical genomics · 2026Article
- 3D printing technology-assisted total hip arthroplasty for acute proximal femoral fracture and Hartofilakidis type II developmental dysplasia of the hip: a case report and literature review.Frontiers in surgery · 2026Article
- Three-years comparative outcomes of S-ROM versus Wagner cone prostheses in total hip arthroplasty with subtrochanteric osteotomy for Crowe IV hip dysplasia.Archives of orthopaedic and trauma surgery · 2025Article
- Using Dynamic Joint Space During Physiological Loading to Objectively Measure Hip Stability.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Prevalence and Morphological Characteristics of the Femoral Head Ossification Nucleus in Chilean Infants: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2025Article
- Selection of experimental animals and modeling methods in developmental dysplasia of the hip research.EFORT open reviews · 2025Review
- Early-Life Trauma as a Trigger for Developmental Myofascial Dysfunction: A Case Report.Cureus · 2025Article
- Minimally-Invasive Dega Osteotomy in Ambulatory Pediatric Patients With Residual Developmental Dysplasia of the Hips-A Technique and Prospective Case Series.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Article
- Impact of Periacetabular Osteotomy on Cartilage Enhancement in Crowe Group I Hip Dysplasia: A Short-Term Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
As one of the most frequent skeletal anomalies, developmental dysplasia of the hip (DDH) is characterized by a considerable range of pathology, from minor laxity of ligaments in the hip joint to complete luxation. Multifactorial etiology, of which the candidate genes have been studied the most, poses a challenge in understanding this disorder. Candidate gene association studies (CGASs) along with genome-wide association studies (GWASs) and genome-wide linkage analyses (GWLAs) have found numerous genes and loci with susceptible DDH association. Studies put major importance on candidate genes associated with the formation of connective tissue (COL1A1), osteogenesis (PAPPA2, GDF5), chondrogenesis (UQCC1, ASPN) and cell growth, proliferation and differentiation (TGFB1). Recent studies show that epigenetic factors, such as DNA methylation affect gene expression and therefore could play an important role in DDH pathogenesis. This paper reviews all existing risk factors affecting DDH incidence, along with candidate genes associated with genetic or epigenetic etiology of DDH in various studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.