ArticleCerebral cortex (New York, N.Y. : 1991)2020
A Domain-General Cognitive Core Defined in Multimodally Parcellated Human Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
183 citing papers in PubMed, 7 syntheses or guidelines pooled it, 357 citations in OpenAlex.
- The Role of the Right Language Network and the Multiple-Demand Network in Verbal Semantics: Insights From an Activation Likelihood Estimation Meta-Analysis of 561 Functional Neuroimaging Studies.Human brain mapping · 2025Pooled it
- Non-literal language processing is jointly supported by the language and theory of mind networks: Evidence from a novel meta-analytic fMRI approach.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Pooled it
- Accurate localization and coactivation profiles of the frontal eye field and inferior frontal junction: an ALE and MACM fMRI meta-analysis.Brain structure & function · 2023Pooled it
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- Multiple dimensions underlying the functional organization of the language network.NeuroImage · 2021Pooled it
- A Cortical Surface-Based Meta-Analysis of Human Reasoning.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- The neural correlates of semantic control revisited.NeuroImage · 2021Pooled it
- Inside a Programmer's Brain: Dissociating Code and Language Comprehension Networks Using a Novel fMRI-ESM Protocol.Human brain mapping · 2026Article
- The cerebellum specializes for language even in the absence of contralateral neocortical inputs.bioRxiv : the preprint server for biology · 2026Article
- What is common to memory retrieval and relational reasoning? Testing neural overlap in anterior lateral prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Preserved topography, lateralization, selectivity, and functional connectivity of the language network in older brains.Nature communications · 2026Article
- Domain-general and language-specific brain networks are differentially associated with verbal intelligence during development.iScience · 2026Article
- Effects of working memory and reward reactivity on externalizing behaviors in the ABCD study.Developmental cognitive neuroscience · 2026Article
- Cognition disconnected: the influence of domain-general cognition (g) in lesion-deficit mapping.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Model-based semantic distance reveals adaptive coordination of distinct cognitive systems in flexible knowledge retrieval.Nature communications · 2026Article
- Individualized parcellation reveals functional boundaries in human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Reduced integrity in the frontal aslant tract's premotor connections is associated with dysfluency severity in stuttering.PNAS nexus · 2026Article
- The human claustrum supports cognitive networks for externally and internally driven task demands.PLoS biology · 2026Article
- Monosynaptic connections link functionally similar regions in human cortex.bioRxiv : the preprint server for biology · 2026Article
- Precision fMRI reveals that the language network exhibits adult-like left-hemispheric lateralization by 4 years of age.Nature communications · 2026Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Numerous brain imaging studies identified a domain-general or "multiple-demand" (MD) activation pattern accompanying many tasks and may play a core role in cognitive control. Though this finding is well established, the limited spatial localization provided by traditional imaging methods precluded a consensus regarding the precise anatomy, functional differentiation, and connectivity of the MD system. To address these limitations, we used data from 449 subjects from the Human Connectome Project, with the cortex of each individual parcellated using neurobiologically grounded multimodal MRI features. The conjunction of three cognitive contrasts reveals a core of 10 widely distributed MD parcels per hemisphere that are most strongly activated and functionally interconnected, surrounded by a penumbra of 17 additional areas. Outside cerebral cortex, MD activation is most prominent in the caudate and cerebellum. Comparison with canonical resting-state networks shows MD regions concentrated in the fronto-parietal network but also engaging three other networks. MD activations show modest relative task preferences accompanying strong co-recruitment. With distributed anatomical organization, mosaic functional preferences, and strong interconnectivity, we suggest MD regions are well positioned to integrate and assemble the diverse components of cognitive operations. Our precise delineation of MD regions provides a basis for refined analyses of their functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.