Evidence map›Paper›PMID 32244188›Full record

ArticleMolecular metabolism2020

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.

Hui Yu, Kavaljit H Chhabra, Zoe Thompson, Graham L Jones, Sylee Kiran, Gary Shangguan, Malcolm J Low

Open access · goldAbstract read
In one paragraph

Article in Molecular metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. G proteins of the GScience advances · 2025
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  14. Obesity: Epidemiology, Pathophysiology, and Therapeutics.Frontiers in endocrinology · 2021 · on this map
    Review
  15. Adiponectin: Role in Physiology and Pathophysiology.International journal of preventive medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hui YuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA. Electronic address: huiyuz@umich.edu.
Kavaljit H ChhabraDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Zoe ThompsonDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.
Graham L JonesNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Sylee KiranDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA; School of Literature, Science, and Arts, University of Michigan, Ann Arbor, MI, USA.
Gary ShangguanDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.
Malcolm J LowDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Martin G Myers · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
Michigan IRACDA: Training Future Professors of Engineering and PhysiologyK12GM111725 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, SEPT, DAVID · 2016 to 2025
$7.9M
Proopiomelanocortin Gene Expression and ObesityR01DK068400 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 2004 to 2022
$6.6M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
SYTEMS AND INTEGRATIVE BIOLOGYT32GM008322 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 1990 to 2020
$5.7M
Neurochemistry/Physiology of Proopiomelanocortin NeuronsR01DK066604 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 2004 to 2019
$5.2M
Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
Role of Hypothalamic MC4R in Glucose Homeostasis via a Novel Neuroendocrine Circuit involving the Kidneys and Adrenal GlandsR01DK124619 · NIDDK · UNIVERSITY OF ROCHESTER · PI CHHABRA, KAVALJIT H · 2021 to 2025
$2.0M
FUNCTION OF THE HYPOTHALAMIC MELANOCORTIN SYSTEM IN STIMULATING COUNTER-REGULATORY RESPONSE TO HYPOGLYCEMIAK01DK113115 · NIDDK · UNIVERSITY OF ROCHESTER · PI CHHABRA, KAVALJIT H · 2017 to 2020
$554k
Prevention of hypoglycemia associated autonomic failure by enhancing melanocortin 4 receptor functionR03DK122190 · NIDDK · UNIVERSITY OF ROCHESTER · PI CHHABRA, KAVALJIT H · 2019 to 2020
$231k
NIDDK NIH HHS K01 DK113115NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK066604NIDDK NIH HHS R01 DK068400NIDDK NIH HHS R01 DK124619NIDDK NIH HHS R03 DK122190NIDDK NIH HHS U2C DK110768NIGMS NIH HHS K12 GM111725NIGMS NIH HHS T32 GM008322NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

objectiveThe steep rise in the prevalence of obesity and its related metabolic syndrome have become a major worldwide health concerns. Melanocortin peptides from hypothalamic arcuate nucleus (Arc) POMC neurons induce satiety to limit food intake. Consequently, Arc Pomc-deficient mice (ArcPomc

methodsCirculating adiponectin was measured in obese ArcPomc

resultsObese ArcPomc

conclusionIn summary, to the best of our knowledge, this study provides the first evidence that despite obesity, the ArcPomc

Indexed as

AdiponectinAdipose Tissuealpha-MSHAnimalsArcuate Nucleus of HypothalamusCaloric RestrictionDisease Models, AnimalFemaleMelanocortinsMetabolism, Inborn ErrorsMiceMice, KnockoutNeuronsObesityPeptides, CyclicPro-OpiomelanocortinAdiponectinalpha-MSHMelanocortinsmelanotan-IIPeptides, CyclicPro-OpiomelanocortinAdiponectinMelanocortin systemPOMCSympathetic nervous system

Identifiers

PMID32244188
PMCPMC7082555
OpenAlexW3004598438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.