ArticleMicrobial pathogenesis2020
Shell disorder analysis predicts greater resilience of the SARS-CoV-2 (COVID-19) outside the body and in body fluids.
Article in Microbial pathogenesis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Systematic review with meta-analysis: SARS-CoV-2 stool testing and the potential for faecal-oral transmission.Alimentary pharmacology & therapeutics · 2020Pooled it
- Clues to Long COVID Linked to Virulence and Infectivity Found in Shell Proteins.Advances in respiratory medicine · 2026Review
- A Comparative Experimental and Computational Study on the Nature of the Pangolin-CoV and COVID-19 Omicron.International journal of molecular sciences · 2024Article
- A narrative review of alternative transmission routes of COVID 19: what we know so far.Pathogens and global health · 2023Review
- SARS-CoV-2 Burden in Wastewater and its Elimination Using Disinfection.Microbiology insights · 2023Review
- Persistence and occurrence of SARS-CoV-2 in water and wastewater environments: a review of the current literature.Environmental science and pollution research international · 2022Review
- Study of the correlation between Covid-19 cases and deaths and basic sanitation in Brazil: Is this a possible secondary route of virus transmission?Journal of hazardous materials advances · 2022Article
- Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics.Biomolecules · 2022Article
- A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation.Biomolecules · 2022Article
- Evaluation of the combined effect of mobility and seasonality on the COVID-19 pandemic: a Lombardy-based study.Acta bio-medica : Atenei Parmensis · 2022Article
- Immunoassay-Compatible Inactivation of SARS-CoV-2 in Plasma Samples for Enhanced Handling Safety.ACS omega · 2022Article
- Shell Disorder Models Detect That Omicron Has Harder Shells with Attenuation but Is Not a Descendant of the Wuhan-Hu-1 SARS-CoV-2.Biomolecules · 2022Article
- Salivary diagnostics of the novel coronavirus SARS-CoV-2 (COVID-19).Oral diseases · 2022Review
- SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19.International journal of molecular sciences · 2022Review
- Understanding COVID-19 Situation in Nepal and Implications for SARS-CoV-2 Transmission and Management.Environmental health insights · 2022Article
- Pulmonary surfactant and COVID-19: A new synthesis.QRB discovery · 2022Article
- The seasonal behaviour of COVID-19 and its galectin-like culprit of the viral spike.Methods in microbiology · 2022Article
- Human Responses in Public Health Emergencies for Infectious Disease Control: An Overview of Controlled Topologies for Biomedical Applications.Contrast media & molecular imaging · 2022Review
- Dangerous liaisons? As the COVID-19 wave hits Africa with potential for novel transmission dynamics: a perspective.Zeitschrift fur Gesundheitswissenschaften = Journal of public health · 2022Article
- SARS-CoV-2 prevalence and transmission in swimming activities: Results from a retrospective cohort study.Scandinavian journal of medicine & science in sports · 2022Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coronavirus (CoV) family consists of viruses that infects a variety of animals including humans with various levels of respiratory and fecal-oral transmission levels depending on the behavior of the viruses' natural hosts and optimal viral fitness. A model to classify and predict the levels of respective respiratory and fecal-oral transmission potentials of the various viruses was built before the outbreak of MERS-CoV using AI and empirically-based molecular tools to predict the disorder level of proteins. Using the percentages of intrinsic disorder (PID) of the nucleocapsid (N) and membrane (M) proteins of CoV, the model easily clustered the viruses into three groups with the SARS-CoV (M PID = 8%, N PID = 50%) falling into Category B, in which viruses have intermediate levels of both respiratory and fecal-oral transmission potentials. Later, MERS-CoV (M PID = 9%, N PID = 44%) was found to be in Category C, which consists of viruses with lower respiratory transmission potential but with higher fecal-oral transmission capabilities. Based on the peculiarities of disorder distribution, the SARS-CoV-2 (M PID = 6%, N PID = 48%) has to be placed in Category B. Our data show however, that the SARS-CoV-2 is very strange with one of the hardest protective outer shell, (M PID = 6%) among coronaviruses. This means that it might be expected to be highly resilient in saliva or other body fluids and outside the body. An infected body is likelier to shed greater numbers of viral particles since the latter is more resistant to antimicrobial enzymes in body fluids. These particles are also likelier to remain active longer. These factors could account for the greater contagiousness of the SARS-CoV-2 and have implications for efforts to prevent its spread.
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