Evidence map›Paper›PMID 32243927›Full record

ArticleLife sciences2020

Estrogen-dependent hypersensitivity to diabetes-evoked cardiac autonomic dysregulation: Role of hypothalamic neuroinflammation.

Mohamed A Fouda, Korin E Leffler, Abdel A Abdel-Rahman

Open access · greenAbstract read
In one paragraph

Article in Life sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Estrogen elicits ferroptosis-related myocardial oxidative stress and dysfunction in male rats.The Journal of pharmacology and experimental therapeutics · 2025
    Article
  3. Article
  4. Article
  5. Heart Failure in Menopause: Treatment and New Approaches.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mohamed A FoudaDepartment of Pharmacology and Toxicology, East Carolina University, Brody School of Medicine, Greenville, NC, United States of America.
Korin E LefflerDepartment of Pharmacology and Toxicology, East Carolina University, Brody School of Medicine, Greenville, NC, United States of America.
Abdel A Abdel-RahmanDepartment of Pharmacology and Toxicology, East Carolina University, Brody School of Medicine, Greenville, NC, United States of America. Electronic address: abdelrahmana@ecu.edu.
East Carolina University · US

Funding

Sex/estrogen-dependent vulnerability to alcohol-evoked cardiotoxicity: Role of circadian rhythm regulated enzymesR01AA014441 · NIAAA · EAST CAROLINA UNIVERSITY · PI ABDEL-RAHMAN, ABDEL A · 2004 to 2022
$5.2M
NIAAA NIH HHS R01 AA014441
6 · The paper itself

Abstract

aimsTo investigate if autonomic dysregulation is exacerbated in female rats, subjected to diabetes mellitus (DM), via a paradoxical estrogen (E MAIN

methodsWe measured cardiac autonomic function and conducted subsequent PVN neurochemical studies, in DM rats, and their respective controls, divided as follows: male, sham operated (SO), ovariectomized (OVX), and OVX with E KEY

findingsAutonomic dysregulation, expressed as sympathetic dominance (higher low frequency, LF, band), only occurred in DM E SIGNIFICANCE: The E

Indexed as

AnimalsApoptosisAutonomic Nervous SystemDeath-Associated Protein KinasesDiabetes ComplicationsDiabetes Mellitus, ExperimentalEstrogensFemaleHeartHeart DiseasesHeart RateHypothalamusInflammationMaleOxidative StressParaventricular Hypothalamic NucleusDapk3 protein, ratDeath-Associated Protein KinasesEstrogensReactive Oxygen SpeciesReceptor, Adenosine A1Receptor, Adenosine A2ATumor Necrosis Factor-alphaAdenosineAutonomic dysregulationDiabetesEstrogenHypothalamus

Identifiers

PMID32243927
PMCPMC7202046
OpenAlexW3014973641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.