ArticleCurrent biology : CB2020
Stress Disrupts Human Hippocampal-Prefrontal Function during Prospective Spatial Navigation and Hinders Flexible Behavior.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness.Molecular psychiatry · 2026Article
- Anxiety, stress, and affective modulation on object-location memory: A systematic review in virtual environments.Cognitive, affective & behavioral neuroscience · 2026Article
- Neighborhood disorder impacts cognitive processing during navigation on a novel virtual reality paradigm.Scientific reports · 2026Article
- Stress disrupts hippocampal integration of overlapping events and memory inference in humans.Science advances · 2026Article
- Cortisol treatment impairs path integration and alters grid-like representations in the male human entorhinal cortex.PLoS biology · 2026Article
- Differential representations of spatial environments in mPFC and hippocampus underpinning flexible navigation.NeuroImage · 2026Article
- A cognitive-motor framework for spatial navigation in aging and early-stage Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Review
- How much time to figure out how to get where? Route planning and subjective stress under time pressure.PloS one · 2025Article
- No effects of acute stress on monetary delay discounting: A systematic literature review and meta-analysis.Neurobiology of stress · 2024Review
- Forming cognitive maps for abstract spaces: the roles of the human hippocampus and orbitofrontal cortex.Communications biology · 2024Article
- Stress affects navigation strategies in immersive virtual reality.Scientific reports · 2024Article
- The neural correlates of memory integration in value-based decision-making during human spatial navigation.Neuropsychologia · 2024Article
- Sex-Specific Alterations in Spatial Memory and Hippocampal AKT-mTOR Signaling in Adult Mice Pre-exposed to Ketamine and/or Psychological Stress During Adolescence.Biological psychiatry global open science · 2024Article
- Threat impairs flexible use of a cognitive map.Motivation and emotion · 2023Article
- Effects of Psychological Interventions on Performance Anxiety in Performing Artists and Athletes: A Systematic Review with Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2023Review
- Neurocognitive Model of Schema-Congruent and -Incongruent Learning in Clinical Disorders: Application to Social Anxiety and Beyond.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Article
- Motivation moderates gender differences in navigation performance.Scientific reports · 2023Article
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Planes, Trains, and Automobiles: Commuting in the 2020s and Beyond.Organizational psychology review · 2023Article
- Vestibular perceptual testing from lab to clinic: a review.Frontiers in neurology · 2023Review
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3 authors.
Funding
Abstract
The ability to anticipate and flexibly plan for the future is critical for achieving goal-directed outcomes. Extant data suggest that neural and cognitive stress mechanisms may disrupt memory retrieval and restrict prospective planning, with deleterious impacts on behavior. Here, we examined whether and how acute psychological stress influences goal-directed navigational planning and efficient, flexible behavior. Our methods combined fMRI, neuroendocrinology, and machine learning with a virtual navigation planning task. Human participants were trained to navigate familiar paths in virtual environments and then (concurrent with fMRI) performed a planning and navigation task that could be most efficiently solved by taking novel shortcut paths. Strikingly, relative to non-stressed control participants, participants who performed the planning task under experimentally induced acute psychological stress demonstrated (1) disrupted neural activity critical for mnemonic retrieval and mental simulation and (2) reduced traversal of shortcuts and greater reliance on familiar paths. These neural and behavioral changes under psychological stress were tied to evidence for disrupted neural replay of memory for future locations in the spatial environment, providing mechanistic insight into why and how stress can alter planning and foster inefficient behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.