Evidence map›Paper›PMID 32243844›Full record

ArticleStem cell reports2020

YAP Non-cell-autonomously Promotes Pluripotency Induction in Mouse Cells.

Amaleah A Hartman, S Maxwell Scalf, Jian Zhang, Xiao Hu, Xinyue Chen, Anna E Eastman, Cindy Yang, Shangqin Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Don't be so naïve.eLife · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Microenvironmental sensing by fibroblasts controls macrophage population size.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amaleah A HartmanCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA.
S Maxwell ScalfCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA.
Jian ZhangCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA.
Xiao HuCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA.
Xinyue ChenCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA.
Anna E EastmanCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA.
Cindy YangCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA.
Shangqin GuoCell Biology Department, Yale University, 10 Amistad Street, Room 131H, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA. Electronic address: shangqin.guo@yale.edu.
Yale Cancer Center · USYale University · US

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
Molecular definition of cancer cell-of-originDP2GM123507 · NIGMS · YALE UNIVERSITY · PI GUO, SHANGQIN · 2016 to 2016
$2.5M
NIGMS NIH HHS DP2 GM123507NIGMS NIH HHS T32 GM007223
6 · The paper itself

Abstract

Yes-associated protein (YAP) is known to promote the stemness of multiple stem cell types, including pluripotent stem cells, while also antagonizing pluripotency during early embryogenesis. How YAP accomplishes these distinct functions remains unclear. Here, we report that, depending on the specific cells in which it is expressed, YAP could exhibit opposing effects on pluripotency induction from mouse somatic cells. Specifically, YAP inhibits pluripotency induction cell-autonomously but promotes it non-cell-autonomously. For its non-cell-autonomous role, YAP alters the expression of many secreted and matricellular proteins, including CYR61. YAP's non-cell-autonomous promoting effect could be recapitulated by recombinant CYR61 and abrogated by CYR61 depletion. Thus, we define a YAP-driven effect on enhancing pluripotency induction largely mediated by CYR61. Our work highlights the importance of considering the distinct contributions from heterologous cell types in deciphering cell fate control mechanisms and calls for careful re-examination of the co-existing bystander cells in complex cultures and tissues.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell DifferentiationCells, CulturedCysteine-Rich Protein 61CytokinesGene Expression Regulation, DevelopmentalMicePluripotent Stem CellsProtein BindingYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCCN1 protein, mouseCell Cycle ProteinsCysteine-Rich Protein 61CytokinesYap1 protein, mouseYAP-Signaling ProteinsCYR61iPSCsnon-cell-autonomouspluripotencystem CellYamanaka reprogrammingYAPyes-associated protein

Identifiers

PMID32243844
PMCPMC7160372
OpenAlexW3014166920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.